INT190167

Context Info Confidence 0.26 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0.82 Pain Relevance 2.76

nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) DNA binding (JUN) cytosol (JUN) peptidase activity (MMP12)

Anatomy Link Frequency macrophages 3 smooth muscle cells 1 JUN (Homo sapiens) MMP12 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 604 100.00 corticosteroid 32 97.76 cINOD 4 96.16 cytokine 80 89.68 Inflammatory stimuli 4 83.12 dexamethasone 28 72.00 Inflammation 88 29.12 Inflammatory mediators 8 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 104 95.76 Asthma 48 92.16 Pulmonary Disease 64 91.28 Airway Remodeling 20 65.12 Emphysema 12 60.00 Cough 16 5.00 Necrosis 12 5.00 Cancer 12 5.00 Disease 8 5.00 Nicotine Addiction 4 5.00

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Removal of the AP-1 binding site from the MMP-12 promoter abolished the basal and inducible expression of MMP-12 [23]. c-Jun, which is a predominant component of the AP-1 binding complex binding to the MMP-12 promoter [23], can potentially transactivate the MMP-12 promoter up to 20-fold in macrophages [18].

AP-1 Binding (complex) of MMP-12 promoter in macrophages associated with metalloproteinase

1) Confidence 0.26 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.08 Pain Relevance 0.72

In vascular smooth muscle cells, PI3-kinase activation appears to be required for MMP-12 transcriptional activity through AP-1 binding to the gene promoter [23].

AP-1 Binding (binding) of MMP-12 in smooth muscle cells associated with metalloproteinase

2) Confidence 0.26 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.57 Pain Relevance 0.57

Removal of the AP-1 binding site from the MMP-12 promoter abolished the basal and inducible expression of MMP-12 [23]. c-Jun, which is a predominant component of the AP-1 binding complex binding to the MMP-12 promoter [23], can potentially transactivate the MMP-12 promoter up to 20-fold in macrophages [18].

Jun Binding (binding) of MMP-12 promoter in macrophages associated with metalloproteinase

3) Confidence 0.23 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.08 Pain Relevance 0.73

Removal of the AP-1 binding site from the MMP-12 promoter abolished the basal and inducible expression of MMP-12 [23]. c-Jun, which is a predominant component of the AP-1 binding complex binding to the MMP-12 promoter [23], can potentially transactivate the MMP-12 promoter up to 20-fold in macrophages [18].

Jun Binding (complex) of MMP-12 promoter in macrophages associated with metalloproteinase

4) Confidence 0.23 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.08 Pain Relevance 0.73

General Comments

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