INT190169

Context Info Confidence 0.30 First Reported 2005 Last Reported 2005 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.74

nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) DNA binding (JUN) cytosol (JUN) peptidase activity (MMP12)

JUN (Homo sapiens) MMP12 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 151 100.00 cytokine 20 99.80 Inflammatory stimuli 1 73.36 Inflammation 22 5.00 corticosteroid 8 5.00 dexamethasone 7 5.00 Inflammatory mediators 2 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 26 73.04 Pulmonary Disease 16 5.00 Asthma 12 5.00 Airway Remodeling 5 5.00 Cough 4 5.00 Necrosis 3 5.00 Cancer 3 5.00 Emphysema 3 5.00 Disease 2 5.00 Nicotine Addiction 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, we examined whether these cytokines affected MMP-12 secretion mediated through regulation of c-Jun activity in ASMC.

Spec (26158) Regulation (regulation) of Jun Spec (whether) Positive_regulation (mediated) of Localization (secretion) of MMP-12 associated with metalloproteinase and cytokine

1) Confidence 0.30 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.07 Pain Relevance 0.74

General Comments

This test has worked.