INT190204

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 31.31
Pain Relevance 13.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP12) extracellular region (MMP12) proteinaceous extracellular matrix (MMP12)
Anatomy Link Frequency
macrophages 14
skin 2
smooth muscle cell 2
respiratory 2
MMP12 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2580 100.00 Very High Very High Very High
cytokine 261 99.88 Very High Very High Very High
Inflammation 638 99.80 Very High Very High Very High
chemokine 13 99.44 Very High Very High Very High
dexamethasone 84 95.44 Very High Very High Very High
corticosteroid 96 93.16 High High
Inflammatory mediators 28 87.08 High High
Inflammatory stimuli 12 84.68 Quite High
cINOD 13 83.52 Quite High
Inflammatory response 35 76.00 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 1790 100.00 Very High Very High Very High
Pulmonary Disease 1353 99.88 Very High Very High Very High
Colon Cancer 4 99.84 Very High Very High Very High
INFLAMMATION 725 99.80 Very High Very High Very High
Disease 90 99.76 Very High Very High Very High
Stress 15 98.80 Very High Very High Very High
Airway Remodeling 60 98.00 Very High Very High Very High
Asthma 146 97.04 Very High Very High Very High
Cough 48 97.04 Very High Very High Very High
Carcinosarcoma 3 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, an increased number of BAL MMP-12+-macrophages in COPD ex-smokers, compared to 'healthy' smoking subjects, let us hypothesize that MMP-12 expression is induced not only by cigarette smoking, but may be an obligatory to the development of COPD.
Positive_regulation (induced) of Gene_expression (expression) of MMP-12 in macrophages associated with nicotine addiction, pulmonary disease and metalloproteinase
1) Confidence 0.67 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.59 Pain Relevance 0.58
induced a time- and concentration-dependent increase in MMP-12 mRNA expression.
Positive_regulation (increase) of Gene_expression (expression) of MMP-12 mRNA associated with metalloproteinase
2) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.87 Pain Relevance 0.62
Overproduction of MMP-12 causes pathological ECM protein breakdown and excessive airway remodeling, which has been implicated in a range of respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD).
Positive_regulation (causes) of Gene_expression (Overproduction) of MMP-12 in respiratory associated with asthma, pulmonary disease, metalloproteinase, respiratory disease and airway remodeling
3) Confidence 0.48 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 1.32 Pain Relevance 0.91
An increased expression of MMP-12 in 'healthy' smokers, also may be a reason for COPD development in the future.


Positive_regulation (increased) of Gene_expression (expression) of MMP-12 associated with pulmonary disease, nicotine addiction and metalloproteinase
4) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.77 Pain Relevance 0.56
stimulated MMP-12 gene expression and activity of ASMC although to lesser extent than IL-1?
Positive_regulation (stimulated) of Gene_expression (expression) of MMP-12 gene associated with metalloproteinase
5) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.05 Pain Relevance 0.64
stimulates a significant enhancement in MMP-12 gene expression, protein production and enzyme secretion, which is mediated by mechanisms involving ERK, JNK, PI3-K and AP-1 signaling pathways.
Positive_regulation (enhancement) of Gene_expression (expression) of MMP-12 gene associated with metalloproteinase
6) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 1.24 Pain Relevance 1.15
Despite different tumoural histology, two cases displayed common microenvironments with expression of VEGF and MMP12, suggesting enhanced macrophage migration and angiogenesis.
Positive_regulation (microenvironments) of Gene_expression (expression) of MMP12 in macrophage
7) Confidence 0.45 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.72 Pain Relevance 0.13
'Healthy' smokers had higher number of BAL MMP-12+-macrophages, than never-smokers supporting the fact of smoking impact in MMP-12 expression.
Positive_regulation (supporting) of Gene_expression (expression) of MMP-12 in macrophages associated with nicotine addiction and metalloproteinase
8) Confidence 0.42 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.79 Pain Relevance 0.57
The amount of BAL MMP-12+-macrophages was also significantly higher in COPD groups than in controls in percentages and absolute values.
Positive_regulation (higher) of Gene_expression (amount) of MMP-12 in macrophages associated with pulmonary disease and metalloproteinase
9) Confidence 0.42 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.88 Pain Relevance 0.37
Macrophages with brown staining in cytoplasm were counted as MMP-12 positive macrophages (MMP-12+-macrophages) (Fig. 1A).
Positive_regulation (macrophages) of Gene_expression (positive) of MMP-12 in macrophages associated with metalloproteinase
10) Confidence 0.42 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 0.08 Pain Relevance 0.38
Although the maximal stimulation of MMP-12 mRNA expression by IL-1?
Positive_regulation (stimulation) of Gene_expression (expression) of MMP-12 mRNA associated with metalloproteinase
11) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.80 Pain Relevance 0.62
-induced MMP-12 activity (Figure 6A) and mRNA expression (Figure 6B).
Positive_regulation (induced) of Gene_expression (expression) of MMP-12 associated with metalloproteinase
12) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.52
Unstimulated ASMC secreted a detectable active form of MMP-12, with a time-dependent enhancement of the secretion after exposing cells with 10 ng/ml IL-1?
Positive_regulation (active) of Gene_expression (detectable) of MMP-12 associated with metalloproteinase
13) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.78
-induced MMP-12 mRNA expression was observed with wortmannin (250 nM), LY294002 (10 ?
Positive_regulation (induced) of Gene_expression (expression) of MMP-12 mRNA associated with metalloproteinase
14) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.61
Smoking and disease itself may stimulate MMP-12 expression in airway compartments (IS and BAL) from COPD patients.



Spec (may) Positive_regulation (stimulate) of Gene_expression (expression) of MMP-12 associated with pulmonary disease, nicotine addiction, metalloproteinase and disease
15) Confidence 0.39 Published 2007 Journal Respir Res Section Abstract Doc Link PMC2200652 Disease Relevance 2.65 Pain Relevance 0.25
Moreover, it let as argue that MMP-12 expression may be induced not only by smoking, but by the disease itself.
Positive_regulation (induced) of Gene_expression (expression) of MMP-12 associated with nicotine addiction, metalloproteinase and disease
16) Confidence 0.39 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.69 Pain Relevance 0.61
Also, we have analysed whether the possible differences in MMP-12 expression are influenced by smoking history and its cessation, as previous animal [17-19] and human [26,27] studies showed, that smoking exposure may increase an expression of MMP-12.
Spec (may) Positive_regulation (increase) of Gene_expression (expression) of MMP-12 associated with nicotine addiction and metalloproteinase
17) Confidence 0.39 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 1.85 Pain Relevance 0.38
An expression of MMP-12 in IS from 'healthy' smokers was increased, compared to never-smokers, supporting the suggestion that smoking may increase an expression of this enzyme.
Positive_regulation (increased) of Gene_expression (expression) of MMP-12 associated with nicotine addiction and metalloproteinase
18) Confidence 0.39 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.26 Pain Relevance 0.60
Also, a higher number of MMP-12+-macrophages in IS and BAL from COPD smokers and COPD ex-smokers, indicates that smoking, which is an initial step contributing to the development of COPD, may stimulate MMP-12 expression in airway cells.
Spec (may) Positive_regulation (stimulate) of Gene_expression (expression) of MMP-12 in macrophages associated with nicotine addiction, pulmonary disease and metalloproteinase
19) Confidence 0.39 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.82 Pain Relevance 0.61
-stimulated MMP-12 mRNA expression and secretion in ASMC.
Positive_regulation (stimulated) of Gene_expression (expression) of MMP-12 mRNA associated with metalloproteinase
20) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.29 Pain Relevance 0.53

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