INT19023

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 5.15
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (B2m)
Anatomy Link Frequency
Clara cell 1
urine 1
B2m (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 5 99.32 Very High Very High Very High
carpal tunnel syndrome 3 92.88 High High
addiction 2 88.48 High High
Paracetamol 3 53.04 Quite High
Inflammation 17 50.00 Quite Low
Analgesic 5 37.68 Quite Low
Central nervous system 11 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 4 99.60 Very High Very High Very High
Renal Disease 18 99.48 Very High Very High Very High
INFLAMMATION 22 99.14 Very High Very High Very High
Alzheimer's Dementia 12 99.04 Very High Very High Very High
Cyst 2 99.04 Very High Very High Very High
Amyloidosis 10 98.58 Very High Very High Very High
Infection 53 97.68 Very High Very High Very High
Hepatic Encephalopathy 3 97.28 Very High Very High Very High
Togavirus Infection 75 96.28 Very High Very High Very High
Carpal Tunnel Syndrome 3 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dialysis-related amyloidosis is a complication of end-stage renal disease (ESRD) that results from retention of beta2-microglobulin (beta2M) and its deposition as amyloid fibrils into osteoarticular tissue.
Localization (retention) of beta2M associated with chronic renal failure, amyloidosis, alzheimer's dementia and renal disease
1) Confidence 0.75 Published 2006 Journal Semin Dial Section Abstract Doc Link 16551286 Disease Relevance 0.85 Pain Relevance 0.13
Dialysis-related amyloidosis is a complication of end-stage renal disease (ESRD) that results from retention of beta2-microglobulin (beta2M) and its deposition as amyloid fibrils into osteoarticular tissue.
Localization (retention) of beta2-microglobulin associated with chronic renal failure, amyloidosis, alzheimer's dementia and renal disease
2) Confidence 0.75 Published 2006 Journal Semin Dial Section Abstract Doc Link 16551286 Disease Relevance 0.85 Pain Relevance 0.13
Some genes related to the inflammatory response, such as Cxcl10, Clu and antigen presentation, such as B2m, Fcer1g showed over-expression only at 72 and 96 hr post infection (Fig 2).
Localization (presentation) of B2m associated with inflammatory response and infection
3) Confidence 0.61 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 0.90 Pain Relevance 0.05
Although retention of beta2-m is a necessary requirement for onset of amyloidosis, it is probably not sufficient.
Localization (retention) of beta2-m associated with amyloidosis
4) Confidence 0.61 Published 2003 Journal Nephrology (Carlton) Section Abstract Doc Link 15012691 Disease Relevance 0.93 Pain Relevance 0.09
Fractional excretion of beta-2-microglobulin in the urine of patients with normal or reduced renal function and hepatic coma.
Localization (excretion) of beta-2-microglobulin in urine associated with hepatic encephalopathy
5) Confidence 0.48 Published 1991 Journal Scand. J. Gastroenterol. Section Title Doc Link 2006396 Disease Relevance 0.98 Pain Relevance 0.05
Urinary excretion of five low molecular weight proteins (LMWP) [beta 2-microglobulin (beta 2m), cystatin C (cyst C), Clara cell protein (CC16), retinol-binding protein (RBP) and alpha 1-microglobulin (alpha 1m)], albumin and N-acetyl-beta-D-glucosaminidase (NAG) were quantified in 16 patients who followed a weight reduction program which included Chinese herbs, which have been incriminated in the genesis of Chinese herbs nephropathy (CHN).
Localization (excretion) of 2-microglobulin in Clara cell associated with weight loss, renal disease and cyst
6) Confidence 0.01 Published 1995 Journal Kidney Int. Section Abstract Doc Link 8544416 Disease Relevance 0.63 Pain Relevance 0

General Comments

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