INT190273

Context Info Confidence 0.07 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.33 Pain Relevance 0

cytosol (CDKN2D) nucleus (CDKN2D) cytoplasm (CDKN2D)

Anatomy Link Frequency P19 1 CDKN2D (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 4 50.00 Rsd 2 5.00 cytokine 2 5.00 Inflammation 1 5.00 adenocard 1 5.00 wide dynamic range 1 5.00

Disease Link Frequency Relevance Heat Cancer 108 99.98 Breast Cancer 97 97.72 Viral Infection 5 96.04 Infection 9 83.92 Carcinoma 4 83.84 Acquired Immune Deficiency Syndrome Or Hiv Infection 6 80.44 Apoptosis 5 54.80 INFLAMMATION 2 48.56 Colon Cancer 3 43.44 Cytomegalovirus Infection 4 25.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

First, we used the TBSV P19 protein to inhibit RNA silencing in mammalian cells and showed that, upon P19 expression, PFV-1 replication was dramatically increased, suggesting that a silencing-related pathway limits viral infection [84].

Gene_expression (expression) of P19 in P19 associated with viral infection

1) Confidence 0.07 Published 2006 Journal Retrovirology Section Body Doc Link PMC1363733 Disease Relevance 0.26 Pain Relevance 0

BRCA2 tumours expressed cyclin D1 and D3, cyclin D kinase (CDK) 4 and the CDK inhibitors, p16, p21, and p27, which were all downregulated in BRCA1.

Gene_expression (expressed) of cyclin D kinase associated with cancer

2) Confidence 0.06 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.07 Pain Relevance 0

General Comments

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