INT190298

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 61
Total Number 63
Disease Relevance 2.66
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MRGPRX1) signal transducer activity (MRGPRX1)
Anatomy Link Frequency
endothelial cells 2
row 1
smooth muscle 1
brain 1
vascular endothelium 1
MRGPRX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 901 100.00 Very High Very High Very High
agonist 755 99.96 Very High Very High Very High
chemokine 108 99.28 Very High Very High Very High
Morphine 195 99.12 Very High Very High Very High
Neurotransmitter 9 95.20 Very High Very High Very High
Glutamate 168 94.72 High High
opiate 21 94.24 High High
Neuropeptide 34 93.16 High High
narcan 9 86.68 High High
antagonist 416 84.16 Quite High
Disease Link Frequency Relevance Heat
Disease 70 96.72 Very High Very High Very High
Targeted Disruption 79 96.40 Very High Very High Very High
Disorder Of Lipid Metabolism 5 95.36 Very High Very High Very High
Adhesions 247 92.96 High High
Neurodegenerative Disease 5 91.44 High High
Cancer 58 86.80 High High
Hypercalcemia 15 84.24 Quite High
Pain 34 81.00 Quite High
Metastasis 6 78.88 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Availability of information about the composition of the interfaces of dimerization/oligomerization will facilitate an understanding of the nature of the interaction between GPCR subunits.
GPCR Binding (interaction) of
1) Confidence 0.46 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
Given that physiologically relevant functional models of GPCRs must incorporate GPCR homo- and/or hetero-oligomeric constructs, the explosion of information about GPCR oligomerization makes this an opportune time for the development of a web-based information system that specifically a) stores computational and experimental information about GPCR oligomerization, and b) allows browsing, visualization and structured querying of its contents.
GPCR Binding (oligomerization) of
2) Confidence 0.46 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
The requirements and ontology described in this manuscript will facilitate the development of future GPCR oligomerization information systems that will integrate data generated by experimental and computational studies of GPCR oligomerization.
GPCR Binding (oligomerization) of
3) Confidence 0.46 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
Based on an interdisciplinary dialog, we have created an ontology that formalizes information concepts and concept relationships required to store the different aspects of GPCR oligomerization in an electronic repository.
GPCR Binding (oligomerization) of
4) Confidence 0.46 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
While classical docking or ligand-based virtual screening strategies focus on each single row independently from the others in this matrix, i.e., treat each target independently from each others, the chemogenomics approach is motivated by the observation that similar molecules can bind similar proteins, and that information about a known interaction between a ligand and a GPCR could therefore be a useful hint to predict interaction between similar molecules and similar GPCRs.
GPCR Binding (interaction) of in row
5) Confidence 0.43 Published 2008 Journal BMC Bioinformatics Section Body Doc Link PMC2553090 Disease Relevance 0 Pain Relevance 0
Providing information about potential mechanisms of activation of GPCR oligomers
GPCR Binding (oligomers) of
6) Confidence 0.36 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
The particular case of asymmetric activation in which one protomer of a GPCR dimer is not capable of G-protein coupling, whereas the other protomer can bind the G-protein but not the ligand will be denoted by the attribute isTransactivated set to TRUE.
GPCR dimer Binding (protomer) of
7) Confidence 0.36 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
The physiological relevance of GPCR oligomerization is largely accepted nowadays, especially in light of the discovered functional implications of GPCR association that include pharmacological diversity, G-protein coupling specificity, downstream signaling amplification or attenuation, and/or internalization (see [1-9] for recent reviews).
GPCR Binding (oligomerization) of
8) Confidence 0.36 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
Antibodies that selectively target GPCR oligomers will also be included in the information system.

10.

GPCR Binding (oligomers) of
9) Confidence 0.36 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0.05
Providing information about the experimental details of the method used in published studies of GPCR oligomers
GPCR Binding (oligomers) of
10) Confidence 0.36 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
Given that physiologically relevant functional models of GPCRs must incorporate GPCR homo- and/or hetero-oligomeric constructs, the explosion of information about GPCR oligomerization makes this an opportune time for the development of a web-based information system that specifically a) stores computational and experimental information about GPCR oligomerization, and b) allows browsing, visualization and structured querying of its contents.
GPCR Binding (oligomerization) of
11) Confidence 0.36 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
Developments at GPCRDB, such as the creation of web services, will facilitate this integration with GPCR-OKB.

3.

GPCR Binding (integration) of
12) Confidence 0.36 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
Providing detailed information about functional roles of GPCR oligomers
GPCR Binding (oligomers) of
13) Confidence 0.36 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0.08
Linking to novel compounds that are proposed to selectively target GPCR oligomers
GPCR Binding (oligomers) of
14) Confidence 0.36 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0.08
Information available about the monomers found in existing resources includes but is not limited to: transmembrane (TM) helical boundaries, sequence alignments, phylogenetic trees, predictions of solvent accessibility of TM residues, snake-like diagrams, three-dimensional (3D) molecular models, Protein Data Bank (PDB) files associated with GPCRs, point mutations, GPCR interacting partners, GPCR cDNAs, chromosomal locations, and ligand-binding constants.
GPCR Binding (interacting) of
15) Confidence 0.34 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
The increase in the frequency and number of reports about GPCR dimerization/oligomerization and the implication of oligomerization in receptor function makes necessary the ability to store and access information about GPCR dimers/oligomers electronically.


GPCR Binding (oligomerization) of
16) Confidence 0.34 Published 2007 Journal BMC Bioinformatics Section Abstract Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
To facilitate the implementation of a comprehensive information system focused on GPCR oligomerization, it is important to make informed decisions about the specific usages the information system will support and what type of information must be stored and queried.
GPCR Binding (oligomerization) of
17) Confidence 0.34 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
From the use case scenarios and system requirements obtained as a result of an interdisciplinary effort, we have incorporated the elements of information that are required to describe sufficiently the phenomena of GPCR homo- and hetero-oligomerization, and also how these elements of information combine to form a system that will serve the targeted users.
GPCR Binding (oligomerization) of
18) Confidence 0.34 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
The GPCR oligomerization ontology that we present here is a formal description of the information concepts required to describe GPCR oligomerization and of the relationships between these concepts.
GPCR Binding (oligomerization) of
19) Confidence 0.34 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
In the meantime, the GPCR-OKB ontology presented here will be useful to database designers and curators who need to manage information about GPCR oligomerization.


GPCR Binding (oligomerization) of
20) Confidence 0.34 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0

General Comments

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