INT190367

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 8.92
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Defa1) extracellular region (Defa1)
Anatomy Link Frequency
enterocytes 1
epithelium 1
intestines 1
Defa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 234 99.96 Very High Very High Very High
Inflammation 267 98.24 Very High Very High Very High
Inflammatory response 13 92.20 High High
Inflammatory stimuli 1 91.20 High High
cytokine 99 87.76 High High
Potency 11 83.84 Quite High
chemokine 22 65.48 Quite High
psoriasis 106 51.12 Quite High
fibrosis 6 41.00 Quite Low
corticosteroid 33 37.60 Quite Low
Disease Link Frequency Relevance Heat
Disease 442 99.96 Very High Very High Very High
Inflammatory Bowel Disease 356 99.84 Very High Very High Very High
Gastritis 26 98.88 Very High Very High Very High
Helicobacter Infection 12 98.40 Very High Very High Very High
INFLAMMATION 232 98.24 Very High Very High Very High
Esophageal Disease 6 94.40 High High
Neutropenia 6 94.08 High High
Psoriasis 144 92.92 High High
Sprains And Strains 112 88.72 High High
Infection 127 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Variability between the different samples from one type of organ was low, and similar profiles of differential expression of beta defensins 1, 2 and 3 were found.
Gene_expression (expression) of defensin
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.28 Pain Relevance 0
The fish defensins contain six conserved cysteines in the region of the mature peptide and three ?
Gene_expression (contain) of defensin
2) Confidence 0.65 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866484 Disease Relevance 0.21 Pain Relevance 0
-defensins are mainly produced by epithelial cells [9], and four subtypes, designated hBD-1 to hBD-4, have been identified in the human mucosa so far. hBD-1 is ubiquitously expressed at all surfaces of the human body including the skin, the respiratory, urogenital and the gastrointestinal tract [10–15]. hBD-2 and hBD-3 are inducible antimicrobial peptides expressed by enterocytes throughout the intestinal tract on demand.
Gene_expression (produced) of defensin in enterocytes
3) Confidence 0.65 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.06 Pain Relevance 0.03
-defensin 1 is expressed constitutively by variety of cell types, while ?
Gene_expression (expressed) of defensin 1
4) Confidence 0.58 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 0.33 Pain Relevance 0.15
Especially in the intestines, a critical balance between luminal bacteria and the antimicrobial peptides is essential, and a breakdown in barrier function by impaired production of defensins is already implicated in Crohn's disease.
Gene_expression (production) of defensin in intestines associated with crohn's disease and disease
5) Confidence 0.58 Published 2010 Journal International Journal of Inflammation Section Abstract Doc Link PMC2992817 Disease Relevance 0.45 Pain Relevance 0.18
Although expression of beta-defensins in some human tissues has been documented before, we wanted to obtain a comprehensive picture of beta-defensin tissue distribution in order to estimate which specific tissues would contribute to systemic protein levels.
Gene_expression (expression) of defensin
6) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.14 Pain Relevance 0.07
Therefore, probiotics such as E.coli Nissle 1917 can reverse the decrease in defensin expression in UC, but not in CD.
Gene_expression (expression) of defensin associated with inflammatory bowel disease and crohn's disease
7) Confidence 0.02 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 1.19 Pain Relevance 0.17
Possibly, lactulose, similarly to the probiotic, could also upregulate defensin expression provided that no genetic mutations have occurred.
Gene_expression (expression) of defensin
8) Confidence 0.02 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 1.23 Pain Relevance 0.20
In UC, defensins are reversibly down-regulated for unknown reasons, whereas in CD, defensin expression is permanently impaired because of genetic alterations.
Gene_expression (expression) of defensin associated with inflammatory bowel disease and crohn's disease
9) Confidence 0.02 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 1.14 Pain Relevance 0.14
the synthesis of defensin expression.
Gene_expression (expression) of defensin
10) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648624 Disease Relevance 0.25 Pain Relevance 0.08
-defensin expression (hBD-2 and hBD-3) could be found, although to a minor degree [31].

3.2.

Gene_expression (expression) of defensin
11) Confidence 0.01 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 1.03 Pain Relevance 0.07
Helicobacter infection is known to lead to a significant induction of hBD-2 (see Figure 1), while the defensin gene expression caused by non-Helicobacter gastritis is much less pronounced [33], a finding which was confirmed in a pediatric cohort [34].
Gene_expression (expression) of defensin gene associated with helicobacter infection and gastritis
12) Confidence 0.01 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.70 Pain Relevance 0.05
In a subsequent mechanistic study the group showed that polymorphonuclear leukocytes (PMNs) reinforce the defensin expression in the epithelium.
Gene_expression (expression) of defensin in epithelium
13) Confidence 0.01 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.97 Pain Relevance 0.04
These findings challenge the perspective that reduced defensin expression is merely the result of epithelial loss in inflammatory states [77].
Gene_expression (expression) of defensin associated with inflammation
14) Confidence 0.01 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.69 Pain Relevance 0.24
defensin 2 (hBD-2), whose expression is upregulated by the presence of several
Gene_expression (expression) of defensin
15) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648624 Disease Relevance 0.25 Pain Relevance 0.08

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