INT190390

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 2.07
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napb) vesicle-mediated transport (Napb)
Anatomy Link Frequency
vesicles 2
neuronal 1
synaptic vesicle 1
soma 1
Napb (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 8 99.92 Very High Very High Very High
halothane 8 99.36 Very High Very High Very High
isoflurane 70 99.08 Very High Very High Very High
Glutamate 415 98.42 Very High Very High Very High
gABA 61 96.48 Very High Very High Very High
antidepressant 156 92.36 High High
Action potential 29 87.92 High High
Botox 1 86.76 High High
Pyramidal cell 89 71.32 Quite High
antagonist 38 69.84 Quite High
Disease Link Frequency Relevance Heat
Stress 655 99.30 Very High Very High Very High
Urological Neuroanatomy 36 51.52 Quite High
Suicidal Behaviour 6 50.08 Quite High
Schizophrenia 48 50.00 Quite Low
Disease 28 35.12 Quite Low
Anxiety Disorder 28 31.60 Quite Low
Depression 28 25.60 Quite Low
Congenital Anomalies 12 17.68 Low Low
Convulsion 13 16.96 Low Low
Body Weight 4 9.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that the modulation of these calcium channels by SNARE protein interactions does not occur in the soma, but may be limited to presynaptic terminals, which lie beyond the level of resolution achieved in these experiments.
SNARE Binding (interactions) of in soma associated with calcium channel
1) Confidence 0.22 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.14
It is conceivable that these functions of dysbindin in the priming and fusion steps may be mediated by its interaction with the SNARE proteins and/or other synaptic vesicle proteins involved in exocytosis (Burgoyne et al., 2001; Burgoyne and Barclay, 2002; Bonanomi et al., 2006).
SNARE Binding (interaction) of in synaptic vesicle
2) Confidence 0.12 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0
97 kD, identified as the ternary SNARE complex, additional intermediate complexes were detected.
SNARE Binding (complex) of
3) Confidence 0.10 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0
It has been proposed that snapin stabilizes the release-ready vesicles by enhancing the interaction of the SNARE proteins with synaptotagmin during the priming process (Tian et al., 2005).
SNARE Binding (interaction) of in vesicles
4) Confidence 0.09 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0
The increase of glutamate release induced in P/FC by footshock stress is accompanied by accumulation of SNARE complexes in the presynaptic membrane
SNARE Binding (complexes) of associated with stress and glutamate
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.79 Pain Relevance 0.43
Previous evidence has shown that the number of SNARE complexes can be increased by chemical treatment of synaptosomes, suggesting a correlation between the accumulation of complexes and the number of vesicles available for release [25].
SNARE Binding (complexes) of in vesicles
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.47 Pain Relevance 0.18
For detection of SDS-resistant SNARE complexes, Western blotting was performed on samples of electrophoresed presynaptic membranes (non-boiled before gel loading) [24]–[26], incubating PVDF membranes containing blotted proteins with monoclonal antibodies for syntaxin-1 1?
SNARE Binding (complexes) of
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0 Pain Relevance 0.19
Measurement of SNARE complex in isolated presynaptic membranes
SNARE Binding (complex) of
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0 Pain Relevance 0.20
It will be interesting to analyze the interaction of different regulatory proteins with the SNARE complex (e.g., synaptotagmin, complexin, ?
SNARE Spec (analyze) Binding (interaction) of
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.41 Pain Relevance 0.24
The presynaptic SNARE complex, consisting of a parallel four-helix bundle formed by the SNARE motifs of the three neuronal SNAREs, represents the core of machinery regulating transmitter release [32]–[34].
SNARE Binding (complex) of in neuronal
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.40 Pain Relevance 0.19
In fact, isoflurane and halothane have recently been reported to bind to syntaxin and the SNARE complex at clinical concentrations [37], although the binding sites on the SNARE proteins have not yet been characterized.
SNARE Binding (bind) of associated with halothane and isoflurane
11) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1369004 Disease Relevance 0 Pain Relevance 0.44

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