INT190619

Context Info Confidence 0.14 First Reported 2006 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.41 Pain Relevance 0.42

signal transduction (F2rl2) plasma membrane (F2rl2) signal transducer activity (F2rl2)

F2rl2 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 23 97.92 cytokine 10 92.68 Inflammation 49 90.00 cva 1 81.36 ischemia 2 75.88 Mechanotransduction 4 64.52 Inflammatory mediators 3 60.80 Arthritis 1 58.92 metalloproteinase 2 51.00 addiction 2 27.88

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 64 99.10 Reprotox - General 1 1 99.08 Atherosclerosis 1 98.88 Injury 57 98.48 Metastasis 1 98.28 Stress 45 93.76 Hypertrophy 3 90.96 INFLAMMATION 59 90.00 Penetrating Head Injuries 5 87.16 Cv General 3 Under Development 1 81.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The induced levels of the protease-activated receptor, PAR-1, were significantly attenuated in IL-1R1-null mice.

Positive_regulation (induced) of protease-activated receptor

1) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.89 Pain Relevance 0.17

At least as attractive, and not mutually exclusive is the hypothesis that arterial injury, like in early atherosclerosis, will up-regulate endothelial expression of proteinase-activated-receptor 2 [53], which will be activated proteolytically within the atherosclerotic lesion and via systemic proteases to specifically sensitize endothelial TRPV4 channels to respond to mechanical stress [34].

Positive_regulation (activated) of proteinase-activated-receptor 2 associated with stress, atherosclerosis, injury and increased venous pressure under development

2) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1959246 Disease Relevance 1.14 Pain Relevance 0.16

Once activated, the serine protease domain of tmprss2 is released from the cell surface into the extracellular space and activates PAR (protease-activated receptor)-2 that has a role in prostate cancer and tumor metastasis [70].

Positive_regulation (activates) of protease-activated receptor associated with metastasis and reprotox - general 1

3) Confidence 0.07 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.37 Pain Relevance 0.08

General Comments

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