INT190996

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCYAP1) extracellular region (ADCYAP1) nucleus (Per1)
protein binding transcription factor activity (Per1) cytoplasm (Per1) signal transducer activity (Per1)
ADCYAP1 (Homo sapiens)
Per1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 22 100.00 Very High Very High Very High
Neurotransmitter 95 82.24 Quite High
depression 2 59.60 Quite High
tolerance 1 39.56 Quite Low
gABA 30 5.00 Very Low Very Low Very Low
Somatostatin 17 5.00 Very Low Very Low Very Low
Neuropeptide 12 5.00 Very Low Very Low Very Low
substance P 11 5.00 Very Low Very Low Very Low
Enkephalin 11 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 7 80.48 Quite High
Chronic Disease 1 63.84 Quite High
Hypertension 9 61.84 Quite High
Diabetes Mellitus 2 60.72 Quite High
Depression 2 59.60 Quite High
Cancer 5 40.16 Quite Low
Lymphatic System Cancer 1 27.36 Quite Low
Targeted Disruption 4 22.72 Low Low
Sleep Disorders 8 7.48 Low Low
Affective Disorder 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Possible genes for glutamate and PACAP thus appear to be the clock genes per1 and per2, which are induced in the SCN by light, glutamate and PACAP at night.
PACAP Positive_regulation (induced) of per1 associated with glutamate
1) Confidence 0.06 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.45 Pain Relevance 0.27

General Comments

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