INT191018

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 8.01
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd79a)
Anatomy Link Frequency
epithelial cells 4
lung 2
T-cell 2
intestine 2
Cd79a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 122 100.00 Very High Very High Very High
chemokine 29 99.60 Very High Very High Very High
Inflammation 40 99.54 Very High Very High Very High
Potency 1 77.60 Quite High
Calcium channel 12 69.84 Quite High
abdominal pain 7 57.76 Quite High
imagery 8 50.00 Quite Low
Inflammatory response 4 46.92 Quite Low
vincristine 4 45.08 Quite Low
Pain 6 32.12 Quite Low
Disease Link Frequency Relevance Heat
Chlamydia Infection 138 100.00 Very High Very High Very High
Food Poisoning 1 99.98 Very High Very High Very High
INFLAMMATION 40 99.54 Very High Very High Very High
Infection 117 99.16 Very High Very High Very High
Immunization 40 98.68 Very High Very High Very High
Parasitic Infection 1 95.28 Very High Very High Very High
Body Weight 23 94.96 High High
Mantle-cell Lymphoma 52 90.36 High High
Sprains And Strains 35 89.60 High High
Salmonella Infection 1 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig. 6, the expression of IgA in the control group increased after BDL, peaked on day 3, and decreased thereafter.
Positive_regulation (increased) of Gene_expression (expression) of IgA
1) Confidence 0.26 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0 Pain Relevance 0.07
BDL induced the expression of IgA in the intestine
Positive_regulation (induced) of Gene_expression (expression) of IgA in intestine
2) Confidence 0.26 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0 Pain Relevance 0.10
Colonic expression of IgA markedly increased after BDL.
Positive_regulation (increased) of Gene_expression (expression) of IgA
3) Confidence 0.26 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0 Pain Relevance 0.05
Given that antibodies are extraordinarily powerful at neutralizing virus, preventing further infection, clearing antigen and even dampening inflammation via FcR ligation, the accelerated IgG and IgA responses in the lung most likely contribute, at least partially, to the enhanced viral clearance in PCN-treated mice.
Positive_regulation (accelerated) of Gene_expression (responses) of IgA in lung associated with inflammation and infection
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.77 Pain Relevance 0.12
These results suggest that CCL5 is required in part for optimal Chlamydia-specific IgA Ab responses during C. muridarum infection.
Positive_regulation (required) of Gene_expression (responses) of IgA associated with chlamydia infection and infection
5) Confidence 0.13 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.86 Pain Relevance 0.24
We have previously shown that chemokines like XCL1 and CCL5 induce IgA production [9,10].
Positive_regulation (induce) of Gene_expression (production) of IgA associated with chemokine
6) Confidence 0.13 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.83 Pain Relevance 0.26
We reported previously that the fermentation of milk at constant pH 6 by L. helveticus R389 increased its content of peptide fractions, and the oral administration of the non-bacterial fraction (FMSpH6) to mice increased total secretory IgA in the intestinal lumen and enhanced the number of IgA and various cytokines producing cells as well as the secretion of IL-6 by small intestine epithelial cells.
Positive_regulation (enhanced) of Gene_expression (producing) of IgA in epithelial cells associated with cytokine
7) Confidence 0.11 Published 2007 Journal BMC Immunol Section Abstract Doc Link PMC2045662 Disease Relevance 0.09 Pain Relevance 0.08
Immunostaining results for CD20, CD79a, CD43, CD5, sIgM(?
Positive_regulation (for) of Gene_expression (sIgM) of CD79a
8) Confidence 0.06 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2853553 Disease Relevance 0.71 Pain Relevance 0
Immunostaining results for CD20, CD79a, CD43, CD5, sIgM(?
Positive_regulation (results) of Gene_expression (sIgM) of CD79a
9) Confidence 0.06 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2853553 Disease Relevance 0.72 Pain Relevance 0
Intestinal infection stimulates the mucosal production of secretory IgA antibodies shown to block the in vitro adherence of Entamoeba histolytica trophozoites to epithelial cells thereby preventing lysis of host cells and damage to tissues [22,23].
Positive_regulation (stimulates) of Gene_expression (production) of IgA in epithelial cells associated with food poisoning
10) Confidence 0.06 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1403785 Disease Relevance 1.45 Pain Relevance 0.08
Serum IgA immune complex (IgA-IC) levels and mesangial IgA deposition increased starting 16 weeks after diet initiation.
Positive_regulation (increased) of Gene_expression (deposition) of IgA
11) Confidence 0.06 Published 2010 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2984136 Disease Relevance 0.60 Pain Relevance 0
Serum IgA immune complex (IgA-IC) levels and mesangial IgA deposition increased starting 16 weeks after diet initiation.
Positive_regulation (increased) of Gene_expression (levels) of IgA
12) Confidence 0.06 Published 2010 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2984136 Disease Relevance 0.66 Pain Relevance 0
Serum IgA immune complex (IgA-IC) levels and mesangial IgA deposition increased starting 16 weeks after diet initiation.
Positive_regulation (increased) of Gene_expression (levels) of IgA
13) Confidence 0.05 Published 2010 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2984136 Disease Relevance 0.67 Pain Relevance 0
Besides for systemic cross-neutralizing antibodies, the induction of H5 specific mucosal IgA that was detected in some ferrets after the first immunization as well as the T-cell response may contribute to the protection of ferrets against a heterologous virus.
Positive_regulation (induction) of Gene_expression (detected) of IgA in T-cell associated with immunization
14) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694350 Disease Relevance 0.65 Pain Relevance 0.04

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