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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Erbb2, Shc1) nucleus (Erbb2, Shc1) cytoplasm (Erbb2, Shc1)
mitochondrion (Shc1) signal transduction (Erbb2) aging (Shc1)
Erbb2 (Mus musculus)
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 25 100.00 Very High Very High Very High
Cancer 158 85.84 High High
Targeted Disruption 8 84.64 Quite High
Malignant Neoplastic Disease 4 75.60 Quite High
Peripheral Arterial Disease 12 72.40 Quite High
Noninfiltrating Intraductal Carcinoma 23 51.00 Quite High
Carcinoma 9 32.32 Quite Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Reprotox - General 2 3 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The signaling pathways activated by PyV-mT include those of Ras, Shc, and phosphotidylinositol 3-kinase, which are frequently activated in human breast cancer (reviewed in [6]) and are also activated by ErbB2 (Her2/neu), a receptor tyrosine kinase that is overexpressed in 30% of breast cancer and is associated with poor outcome [7].
ErbB2 Positive_regulation (activated) of Shc associated with breast cancer
1) Confidence 0.08 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.95 Pain Relevance 0

General Comments

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