INT191099

Context Info Confidence 0.08 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.95 Pain Relevance 0

plasma membrane (Erbb2, Shc1) nucleus (Erbb2, Shc1) cytoplasm (Erbb2, Shc1) mitochondrion (Shc1) signal transduction (Erbb2) aging (Shc1)

Erbb2 (Mus musculus) Shc1 (Mus musculus)

Pain Link Frequency Relevance Heat addiction 2 5.00 Pain 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 25 100.00 Cancer 158 85.84 Targeted Disruption 8 84.64 Malignant Neoplastic Disease 4 75.60 Peripheral Arterial Disease 12 72.40 Noninfiltrating Intraductal Carcinoma 23 51.00 Carcinoma 9 32.32 Apoptosis 8 5.00 Reprotox - General 2 3 5.00 Sleep Disorders 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The signaling pathways activated by PyV-mT include those of Ras, Shc, and phosphotidylinositol 3-kinase, which are frequently activated in human breast cancer (reviewed in [6]) and are also activated by ErbB2 (Her2/neu), a receptor tyrosine kinase that is overexpressed in 30% of breast cancer and is associated with poor outcome [7].

ErbB2 Positive_regulation (activated) of Shc associated with breast cancer

1) Confidence 0.08 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.95 Pain Relevance 0

General Comments

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