INT191101

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2009
Negated 1
Speculated 3
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 2.49
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
plasma 4
monocyte 3
endothelial cells 2
HL-60 2
macrophages 1
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 74 99.82 Very High Very High Very High
metalloproteinase 128 97.28 Very High Very High Very High
Nicotine 86 94.44 High High
cytokine 11 66.56 Quite High
Inflammatory response 4 34.64 Quite Low
agonist 1 31.28 Quite Low
Pain 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 86 99.82 Very High Very High Very High
Nicotine Addiction 59 95.36 Very High Very High Very High
Cancer 132 94.00 High High
Disease 17 88.44 High High
Atherosclerotic Plaque 6 87.60 High High
Bladder Cancer 29 87.48 High High
Bacterial Infection 2 83.60 Quite High
Renal Cancer 4 81.76 Quite High
Apoptosis 49 80.56 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 74.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The plasma of all study participants exhibited an inhibitory effect on LPS-induced MMP-9 secretion, but interindividual variations were obvious.
Regulation (effect) of Localization (secretion) of MMP-9 in plasma
1) Confidence 0.38 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0 Pain Relevance 0
The fact that the expression of Rho GTPase induces clustering of CD44 and MMP-9 in the advancing lamellipodia of endothelial cells [33] prompted us to determine the effects BP on the localization of CD44 and MMP-9 in the indicated PC3 cell lines.
Spec (determine) Regulation (effects) of Spec (determine) Localization (localization) of MMP-9 in endothelial cells
2) Confidence 0.34 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.22 Pain Relevance 0
MMP-9 secretion was dose-dependently down-regulated by clodronate in human monocyte/macrophages [30].
Regulation (regulated) of Localization (secretion) of MMP-9 in monocyte
3) Confidence 0.29 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].
Regulation (regulated) of Localization (forms) of MMP9 associated with metalloproteinase
4) Confidence 0.24 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.83 Pain Relevance 0.23
We determined how these PUFAs influence MMP-9 expression and secretion by the human monocytic cell line (MonoMac 6) at baseline and after 24-hour exposure.
Spec (determined) Regulation (influence) of Localization (secretion) of MMP-9
5) Confidence 0.23 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2667508 Disease Relevance 0.36 Pain Relevance 0.18
EPA, DPA or DHA, fatty acids of the n-3 series, which are considered to be anti-inflammatory, had no effect on basal secretion of MMP-9.
Neg (no) Regulation (effect) of Localization (secretion) of MMP-9 associated with inflammation
6) Confidence 0.23 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.16 Pain Relevance 0.05
We investigated a potential influence of the plasma samples on LPS-induced release of MMP-9 from human monocytes.
Spec (investigated) Regulation (influence) of Localization (release) of MMP-9 in plasma
7) Confidence 0.23 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0.17 Pain Relevance 0.08
While HL-60 cells are highly resistant to physiologically relevant doses of nicotine during differentiation, with respect to alterations to cell proliferation, viability, cell cycle, ultrastructural characteristics and the development of terminal differentiation markers, key effector functions are suppressed (oxidative burst and bactericidal capacity) and the release of the MMP-9 is dysregulated.
Regulation (dysregulated) of Localization (release) of MMP-9 in HL-60 associated with nicotine
8) Confidence 0.17 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 0.74 Pain Relevance 0.27
MMP-9 secretion was dose-dependently down-regulated by clodronate in human monocyte/macrophages [30].
Regulation (regulated) of in macrophages Localization (secretion) of MMP-9 in monocyte
9) Confidence 0.10 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0

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