INT19134

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Context Info
Confidence 0.66
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 11.61
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSAB1) extracellular space (TPSAB1) extracellular region (TPSAB1)
Anatomy Link Frequency
reticulocytes 2
liver 1
bone marrow 1
bladder 1
nasal 1
TPSAB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 13 100.00 Very High Very High Very High
Angina 17 97.84 Very High Very High Very High
anesthesia 2 96.96 Very High Very High Very High
Pain 14 92.80 High High
cva 5 91.92 High High
Inflammatory mediators 1 86.80 High High
Inflammation 9 83.68 Quite High
interstitial cystitis 1 80.20 Quite High
backache 1 78.56 Quite High
imagery 5 76.08 Quite High
Disease Link Frequency Relevance Heat
Adhesions 14 99.14 Very High Very High Very High
Hypotension 43 99.12 Very High Very High Very High
Mastocytosis 7 98.54 Very High Very High Very High
Anaphylaxis 318 98.52 Very High Very High Very High
Angina 16 97.84 Very High Very High Very High
Emergencies 26 97.64 Very High Very High Very High
Hypersensitivity 45 95.72 Very High Very High Very High
Rupture 2 95.44 Very High Very High Very High
Cirrhosis 2 94.20 High High
Atherosclerosis 5 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Tryptase levels are elevated during spontaneous ischemic episodes in unstable angina but not after the ergonovine test in variant angina].
Gene_expression (levels) of Tryptase associated with angina
1) Confidence 0.66 Published 1998 Journal Cardiologia Section Title Doc Link 9557375 Disease Relevance 0.84 Pain Relevance 0.62
Detection of tryptase was evaluated with several body fluids and was accurate in sera, plasma, bronchoalveolar lavage fluid, nasal lavage fluid, and saliva.
Gene_expression (Detection) of tryptase in body
2) Confidence 0.60 Published 1991 Journal J. Immunol. Methods Section Abstract Doc Link 2019745 Disease Relevance 0.07 Pain Relevance 0.07
The immunoassay also was utilized to examine serum levels of tryptase after the onset of a hypotensive reaction in one patient receiving general anesthesia.
Spec (examine) Gene_expression (levels) of tryptase associated with anesthesia and hypotension
3) Confidence 0.60 Published 1991 Journal J. Immunol. Methods Section Abstract Doc Link 2019745 Disease Relevance 0.10 Pain Relevance 0.10
To assess whether or not activation of mast cells is a primary event, we measured serum levels of tryptase, a specific marker of mast cell activation, in 8 patients with unstable angina during a spontaneous ischemic episode (Group 1) and in 5 patients with variant angina (Group 2) during ergonovine-induced coronary spasm.
Gene_expression (levels) of tryptase in mast cell associated with angina and cva
4) Confidence 0.59 Published 1998 Journal Cardiologia Section Abstract Doc Link 9557375 Disease Relevance 0.86 Pain Relevance 0.62
Diagnosis is based on the presence of mast cells in Giemsa-stained liver histological sections, and it may be confirmed by immunohistochemical detection of tryptase in the cytoplasm of these abnormally proliferating cells.
Gene_expression (detection) of tryptase in liver
5) Confidence 0.59 Published 1998 Journal Am. J. Gastroenterol. Section Abstract Doc Link 9448186 Disease Relevance 1.11 Pain Relevance 0.08
Prostacyclin production in tryptase and thrombin stimulated human bladder endothelial cells: effect of pretreatment with phospholipase A2 and cyclooxygenase inhibitors.
Gene_expression (production) of tryptase in bladder
6) Confidence 0.38 Published 2006 Journal J. Urol. Section Title Doc Link 16952710 Disease Relevance 0.25 Pain Relevance 0.16
Histamine, tryptase and beta-tryptase levels have proved useful in confirming acute IgE mediated reactions, but negative results do not rule out acute allergic reactions.2627In selected cases re-exposure may be of value; however, considering the degree of drug reaction and risks, this is usually not advisable.Prick or scratch test: Emergency resuscitation equipment should be available.
Gene_expression (levels) of tryptase associated with adverse drug reaction, emergencies and hypersensitivity
7) Confidence 0.28 Published 2008 Journal Indian Journal of Dermatology Section Body Doc Link PMC2784579 Disease Relevance 0.94 Pain Relevance 0.04
However, the bone marrow exhibited the typical picture of mastocytosis, with disseminated clusters of differentiated spindle-shaped cells that stained strongly for tryptase, c-kit, and chloroacetate esterase.
Gene_expression (stained) of tryptase in bone marrow associated with mastocytosis
8) Confidence 0.27 Published 1997 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 9140315 Disease Relevance 1.18 Pain Relevance 0.07
In an emergency department study, elevated histamine levels were observed in 42 of 97 patients, but only 20 also exhibited increased tryptase levels [30].
Gene_expression (levels) of tryptase associated with emergencies
9) Confidence 0.21 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873621 Disease Relevance 1.03 Pain Relevance 0
However, tryptase levels may not be elevated in all forms of anaphylaxis (eg, it is frequently normal in foodassociated anaphylaxis) [18,30].
Gene_expression (levels) of tryptase associated with anaphylaxis
10) Confidence 0.21 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873621 Disease Relevance 1.31 Pain Relevance 0
Histamine and tryptase elevations do not necessarily correlate.
Gene_expression (elevations) of tryptase
11) Confidence 0.18 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873621 Disease Relevance 0.92 Pain Relevance 0
Furthermore, increased levels of eosinophil cationic protein (ECP) and albumin, but not tryptase, in nasal lavage from workers exposed to UV coatings have been observed.
Gene_expression (levels) of tryptase in nasal
12) Confidence 0.13 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11678174 Disease Relevance 0.21 Pain Relevance 0.13
In vitro, human astrocytes expressed high levels of TPS-1, which was detected intracellularly and at the cell surface (Figure 3A-D).
Gene_expression (expressed) of TPS-1 in astrocytes
13) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.34 Pain Relevance 0
Whereas both TPs are expressed in VSMCs, TP?
Gene_expression (expressed) of TPs
14) Confidence 0.08 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.06
Recently, a new adhesion pathway has been described between VCAM-1 expressed on cytokine stimulated endothelium and the alpha 4 beta 1 integrin complex expressed on sickle reticulocytes.
Gene_expression (expressed) of alpha 4 beta 1 in reticulocytes associated with adhesions and cytokine
15) Confidence 0.01 Published 1995 Journal Blood Section Abstract Doc Link 7537985 Disease Relevance 1.02 Pain Relevance 0.20
Recently, a new adhesion pathway has been described between VCAM-1 expressed on cytokine stimulated endothelium and the alpha 4 beta 1 integrin complex expressed on sickle reticulocytes.
Gene_expression (expressed) of alpha 4 beta 1 in reticulocytes associated with adhesions and cytokine
16) Confidence 0.01 Published 1995 Journal Blood Section Abstract Doc Link 7537985 Disease Relevance 1.02 Pain Relevance 0.20
It has previously been reported that sickle reticulocytes express the alpha 4 beta 1 integrin receptor and bind to cytokine-activated endothelium via an alpha 4 beta 1/vascular-cell adhesion molecule-1 (VCAM-1) interaction.
Gene_expression (express) of alpha 4 beta 1 in endothelium associated with adhesions and cytokine
17) Confidence 0.01 Published 1996 Journal Blood Section Abstract Doc Link 8943872 Disease Relevance 0.43 Pain Relevance 0.14

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