INT191343

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 11.30
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IDO1) small molecule metabolic process (IDO1) oxidoreductase activity (IDO1)
cellular nitrogen compound metabolic process (IDO1)
Anatomy Link Frequency
HGF 2
T-cell 2
nerve 1
NK cells 1
IDO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 24 99.72 Very High Very High Very High
Pain 183 99.28 Very High Very High Very High
cINOD 105 98.90 Very High Very High Very High
Eae 10 96.84 Very High Very High Very High
cytokine 418 92.88 High High
Inflammation 487 92.48 High High
dorsal root ganglion 6 91.20 High High
unmyelinated 36 91.04 High High
c fibre 66 90.52 High High
hyperexcitability 6 90.08 High High
Disease Link Frequency Relevance Heat
Bladder Disease 204 100.00 Very High Very High Very High
Overactive Bladder 184 100.00 Very High Very High Very High
Glioblastoma 38 100.00 Very High Very High Very High
Communicable Diseases 22 99.48 Very High Very High Very High
Encephalopathy 27 98.88 Very High Very High Very High
Disease 151 98.60 Very High Very High Very High
Cancer 128 98.52 Very High Very High Very High
Influenza Virus Infection 12 98.28 Very High Very High Very High
Pain 140 97.44 Very High Very High Very High
Incontinence 32 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression levels of known MSC immune-modulatory molecules such as IDO, HGF and COX2 generated PGE2 differed in culture supernatants of both the MSCs (Figure 5).
Gene_expression (Expression) of IDO in HGF associated with cox2
1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.31 Pain Relevance 0.29
IDO has not been shown to be expressed by MSCs but is inducible by IFN?.
Gene_expression (expressed) of IDO
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.06 Pain Relevance 0.09
Differences in mRNA expression of IDO, HGF, COX2 and CIITA was consistently observed (Figure 5A).
Gene_expression (expression) of IDO in HGF associated with cox2
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.08 Pain Relevance 0.09
Similar positive and improved results were observed by Loch t al.[13] using 200 units of botulinum toxin in IDO and Zermann et al.[14]
Gene_expression (observed) of IDO
4) Confidence 0.42 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684267 Disease Relevance 0.58 Pain Relevance 0.23
IDO is an IFN?
Gene_expression (is) of IDO
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.07 Pain Relevance 0.09
inducible IDO activity was higher in IFN?
Gene_expression (activity) of IDO
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.06 Pain Relevance 0.09
induced IDO production by MSCs was shown to be the key player in immuno-suppression of T cells [34].
Gene_expression (production) of IDO in T cells
7) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 1.14 Pain Relevance 0.45
Moreover, pDCs also produce indolamine 2, 3 dioxigenase (IDO), which is an enzyme activated by both type I and type II Interferon, and is involved in tryptophan catabolism.
Gene_expression (produce) of IDO
8) Confidence 0.37 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 1.14 Pain Relevance 0.23
(produced by T cells and natural killer [NK] cells) to stimulate IDO production by MPCs, which in turn inhibits the proliferation of activated T or NK cells. [13].
Gene_expression (production) of IDO in NK cells
9) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0 Pain Relevance 0
Again, as depicted in Fig. 4D, a contrasting effect Indo was found: increasing concentrations of Indo induced higher turbidity measurements in DPPC suspensions (closed diamonds) and a significant decrease in turbidity of DOPC suspension (open squares).
Gene_expression (found) of Indo
10) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0.16
The energy transfer between t-PnA and DOPE-NBD was minimally changed by Indo (Fig. 2B), possibly because the FRET efficiency between the probes was extremely low (?
Gene_expression (changed) of Indo
11) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0
0.11 at 3.5 mM Indo, a ?
Gene_expression (0.11) of Indo
12) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0.05
0.16 without Indo to ?
Gene_expression (0.16) of Indo
13) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0
Yet, we found no change in FRET efficiency in DOPC membrane exposed to the NSAID, suggesting that possible loosened packing is not the source for Indo-induced changes in FRET efficiency observed in the mixed membranes.
Gene_expression (source) of Indo associated with cinod
14) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0.10
However, Pree et al found divergent results regarding the role of IDO in vivo (Pree et al 2007).
Gene_expression (role) of IDO
15) Confidence 0.18 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.08 Pain Relevance 0.10
There was no statistically significant difference in the TRPM8 urothelial immunostaining between controls and IDO (P = 0.1555) or PBS (P = 0.1816) groups (Fig 3b).


Gene_expression (controls) of IDO associated with bladder disease
16) Confidence 0.18 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.83 Pain Relevance 0.31
In contrast, in IDO and PBS bladders, TRPM8-immunoreactive fibres were seen in nerve bundles along with fine fibres scattered in the suburothelium.
Gene_expression (bladders) of IDO in nerve associated with bladder disease
17) Confidence 0.18 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.38 Pain Relevance 0.39
While there was no significant difference in urothelial TRPM8 immunostaining in PBS and IDO specimens or its correlation with clinical scores, further studies using different methods of quantification, turnover and function of urothelial TRPM8 receptors are necessary before it is concluded that they do not play a role in the pathophysiology of IDO or PBS.
Gene_expression (immunostaining) of IDO associated with bladder disease
18) Confidence 0.18 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 1.14 Pain Relevance 0.83
Compared to controls, a three- and five-fold increase of TRPM8-immunoreactive axons was seen in IDO and PBS groups respectively.
Gene_expression (groups) of IDO associated with bladder disease
19) Confidence 0.18 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.73 Pain Relevance 0.15
The myelin stained fibres also showed a two-fold increase in the PBS and IDO groups, but this was not statistically significant (PBS, P = 0.143, IDO, P = 0.076; Fig 3d).
Gene_expression (groups) of IDO associated with bladder disease
20) Confidence 0.18 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.81 Pain Relevance 0.22

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