INT191417

Context Info Confidence 0.18 First Reported 2005 Last Reported 2008 Negated 2 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 3.16 Pain Relevance 0.74

Anatomy Link Frequency mononuclear cells 1 Rf (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 137 100.00 alcohol 6 92.72 Arthritis 4 91.20 Pain 22 77.72 Inflammatory marker 4 33.04 Osteoarthritis 44 17.60 Inflammation 18 5.00 depression 10 5.00 methotrexate 3 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 143 100.00 Anaerobic Bacterial Infections 10 98.70 Diabetes Mellitus 26 97.92 Asthma 22 96.88 Nicotine Addiction 28 82.00 Pain 23 77.72 Disease 37 75.00 Obesity 30 73.12 Fatigue 20 47.12 INFLAMMATION 21 33.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Chronic drinkers were significantly less likely to report poor general health or poor physical health than those who were not chronic drinkers, but significantly more likely to report "RF worried tense or anxious" or "RF lack of rest or sleep".

Neg (lack) Localization (report) of RF

1) Confidence 0.18 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1431510 Disease Relevance 0.96 Pain Relevance 0.12

Chronic drinkers were significantly less likely to report poor general health or poor physical health than those who were not chronic drinkers, but significantly more likely to report "RF worried tense or anxious" or "RF lack of rest or sleep".

Neg (lack) Localization (report) of RF

2) Confidence 0.18 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1431510 Disease Relevance 0.98 Pain Relevance 0.12

Using this method, both anti-CCP IgG and anti-tetanus IgG as well as total IgM and IgG were found to be significantly enriched in RA synovia, whereas the value for RF-IgM did not differ significantly from 1.

Localization (enriched) of RF associated with rheumatoid arthritis and anaerobic bacterial infections

3) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.51 Pain Relevance 0.17

Similarly, dispersed cells from rheumatoid synovia synthesize immunoglobulins [12,13] and RF [13-15], and synovial fluid-derived mononuclear cells secrete anti-CCP antibodies [16].

Localization (secrete) of RF in mononuclear cells

4) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.09 Pain Relevance 0.04

The purpose of this study is to compare the clinical characteristics and treatment patterns of RA according to the presence of RF in Korean patients.

Localization (presence) of RF associated with rheumatoid arthritis

5) Confidence 0.02 Published 2005 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2815829 Disease Relevance 0.62 Pain Relevance 0.27

General Comments

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