INT191686

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.79
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sgk1) endoplasmic reticulum (Sgk1) plasma membrane (Sgk1)
nucleus (Sgk1) kinase activity (Sgk1) response to stress (Sgk1)
Igh-Dex (Mus musculus)
Sgk1 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 144 100.00 Very High Very High Very High
Chronic pancreatitis 2 90.32 High High
corticosteroid 2 50.00 Quite Low
palliative 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 82 99.08 Very High Very High Very High
Apoptosis 72 97.64 Very High Very High Very High
Breast Cancer 14 90.48 High High
Pancreatitis 2 90.32 High High
Carcinoma 6 71.08 Quite High
Death 4 64.16 Quite High
Lymphatic System Cancer 4 55.32 Quite High
Skin Cancer 4 54.76 Quite High
Solid Tumor 10 45.12 Quite Low
Reprotox - General 1 6 44.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, we found DEX-induced upregulation of the pro-survival genes SGK-1 and MKP-1.
DEX Positive_regulation (upregulation) of SGK-1 associated with dexamethasone
1) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.16 Pain Relevance 0.22
During a time kinetic from 24 to 72 h, DEX strongly enhanced the levels of MKP-1, SGK1 and X-IAP, in several pancreatic cancer cell lines examined, while Bcl-2 expression was only marginally increased.
DEX Positive_regulation (enhanced) of SGK1 associated with pancreatic cancer and dexamethasone
2) Confidence 0.02 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.63 Pain Relevance 0.24

General Comments

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