INT191762

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.84 Pain Relevance 0.56

endosome (FPR1) signal transduction (FPR1) plasma membrane (FPR1) signal transducer activity (FPR1)

FPR1 (Homo sapiens) IGKV1D-39 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 58 84.08 Analgesic 10 84.08 Eae 4 73.64 imagery 4 72.88 cINOD 12 47.64 Inflammatory stimuli 4 41.76 carrageenan induced 2 25.84 Kinase C 10 5.00 cytokine 6 5.00 chemokine 2 5.00

Disease Link Frequency Relevance Heat Adhesions 82 98.08 INFLAMMATION 70 84.08 Cancer 4 81.44 Necrosis 4 80.96 Pressure And Volume Under Development 6 26.40 Disease 8 5.00 Atherosclerosis 4 5.00 Diabetes Mellitus 2 5.00 Hypertension 2 5.00 Arthritis 2 5.00

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Negation

Speculation

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The compounds' effects on the production of reactive oxygen species (ROS) by human polymorphonuclear cells (PMNs) were studied in an in vitro cell model, evaluating inhibition of superoxide anion (O2-.) production induced by N-formylmethionyl-leucyl-phenylalanine (FMLP).

FMLP Positive_regulation (induced) of Gene_expression (production) of O2

1) Confidence 0.01 Published 2006 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1435878 Disease Relevance 0.64 Pain Relevance 0.46

Effect on O2-. production induced by FMLP on PMNs

FMLP Positive_regulation (induced) of Gene_expression (production) of O2

2) Confidence 0.01 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.20 Pain Relevance 0.10

General Comments

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