INT19177

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Context Info
Confidence 0.53
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 12.65
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GRHPR) oxidoreductase activity (GRHPR) cellular nitrogen compound metabolic process (GRHPR)
cytoplasm (GRHPR)
Anatomy Link Frequency
brains 2
plasma 1
lower urinary tract 1
liver 1
hepatocytes 1
GRHPR (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 20 99.26 Very High Very High Very High
qutenza 9 98.48 Very High Very High Very High
Potency 4 98.46 Very High Very High Very High
Bile 6 98.16 Very High Very High Very High
aspirin 22 97.66 Very High Very High Very High
Angina 24 97.32 Very High Very High Very High
beta blocker 21 88.40 High High
Pain 15 80.72 Quite High
abdominal pain 4 78.64 Quite High
nud 1 76.72 Quite High
Disease Link Frequency Relevance Heat
Overactive Bladder 167 99.48 Very High Very High Very High
INFLAMMATION 52 99.14 Very High Very High Very High
Hyperlipidemia 26 99.12 Very High Very High Very High
Benign Prostatic Hypertrophy 54 98.84 Very High Very High Very High
Apoptosis 49 98.84 Very High Very High Very High
Parkinson's Disease 7 97.72 Very High Very High Very High
Lower Urinary Tract Symptoms 9 97.64 Very High Very High Very High
Cv General 3 Under Development 25 97.32 Very High Very High Very High
Diabetes Mellitus 48 96.96 Very High Very High Very High
Schizophrenia 74 96.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the pharmacological potency of nonsteroidal anti-inflammatory drugs may be predicted from the degree of inhibition of BF reductase by these drugs.
Negative_regulation (inhibition) of BF reductase associated with inflammation, cinod and potency
1) Confidence 0.53 Published 1991 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2024065 Disease Relevance 0.35 Pain Relevance 0.40
BF reductase was strongly inhibited by a variety of nonsteridal anti-inflammatory drugs and then a significant correlation was observed between the logarithms of IC50 (concentration required to produce 50% inhibition of BF reductase activity) values and the maximal daily human doses for nonsteroidal anti-inflammatory drugs.
Negative_regulation (inhibited) of BF reductase associated with inflammation and cinod
2) Confidence 0.53 Published 1991 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2024065 Disease Relevance 0.26 Pain Relevance 0.37
BF reductase was strongly inhibited by a variety of nonsteridal anti-inflammatory drugs and then a significant correlation was observed between the logarithms of IC50 (concentration required to produce 50% inhibition of BF reductase activity) values and the maximal daily human doses for nonsteroidal anti-inflammatory drugs.
Negative_regulation (inhibition) of BF reductase associated with inflammation and cinod
3) Confidence 0.53 Published 1991 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2024065 Disease Relevance 0.27 Pain Relevance 0.40
3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors are gaining widespread use in the treatment of hypercholesterolemia.
Negative_regulation (inhibitors) of ) reductase associated with hyperlipidemia
4) Confidence 0.37 Published 1990 Journal Cardiology Section Abstract Doc Link 2073673 Disease Relevance 0.48 Pain Relevance 0.15
The advent of the HMG CoA reductase inhibitors in the late 1980s has had a revolutionary impact in the clinical management of hypercholesterolaemia, not only because of their efficacy but especially because they are well-tolerated.
Negative_regulation (inhibitors) of reductase associated with hyperlipidemia
5) Confidence 0.17 Published 2001 Journal Expert Opin Pharmacother Section Abstract Doc Link 11336596 Disease Relevance 0.83 Pain Relevance 0.13
In ischaemic heart conditions we report a remarkable increase in platelet xanthine oxidase activity and rise in the levels of malondialdehyde (MDA) with concomitant decrease in the activities of free radical scavenging enzymes - superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase.
Negative_regulation (decrease) of reductase in platelet
6) Confidence 0.03 Published 2000 Journal Int. J. Cardiol. Section Abstract Doc Link 11121594 Disease Relevance 0.15 Pain Relevance 0.07
The distinct effect of capsaicin-induced apoptosis on the expression pattern of HepG2 proteins includes the downregulation of some antioxidant enzymes including aldose reductase (AR), catalase, enolase 1, peroxiredoxin 1, but upregulation of peroxiredoxin 6, cytochrome c oxidase, and SOD2.
Negative_regulation (downregulation) of reductase associated with qutenza and apoptosis
7) Confidence 0.02 Published 2008 Journal Proteomics Section Abstract Doc Link 18991268 Disease Relevance 0.73 Pain Relevance 0.58
They act by inhibiting HMGCoA reductase, a fundamental enzyme to produce cholesterol–LDL complexes in the liver.
Negative_regulation (inhibiting) of reductase in liver
8) Confidence 0.01 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656963 Disease Relevance 1.28 Pain Relevance 0
Use of prophylactic 5 a-reductase inhibitors can prevent AUR in men with BPH having moderate to severe lower urinary tract symptoms and large prostate size.
Negative_regulation (inhibitors) of a-reductase in lower urinary tract associated with benign prostatic hypertrophy, overactive bladder and lower urinary tract symptoms
9) Confidence 0.01 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Abstract Doc Link PMC2721562 Disease Relevance 1.59 Pain Relevance 0
Thus, our data do not directly support the view that statins would cause mitochondrial dysfunction by reducing ubiquinone, a mitochondrial coenzyme with a cholesterol synthetic pathway derived side-chain, due to inhibition of HMG-CoA reductase in the muscle.
Negative_regulation (inhibition) of reductase in muscle associated with parkinson's disease
10) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762369 Disease Relevance 0.44 Pain Relevance 0.04
This was based on potential synergy between gemcitabine and capecitabine as a result of gemcitabine inhibiting ribonucleotide reductase thus depleting intracellular pools of deoxyuridine monophosphate and leading to enhanced binding of 5-fluorodeoxyuridine monophosphate, the active metabolite of fluorouracil, to thymidylate synthase (Ren et al. 1998) (Fig. 1).
Negative_regulation (inhibiting) of reductase
11) Confidence 0.01 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012429 Disease Relevance 0.78 Pain Relevance 0.08
In addition, fibrates have been shown to decrease cholesterol synthesis by inhibiting hydroxymethylglutamyl-coenzyme A reductase and to increase cholesterol excretion in the bile pool.55,60,61 Fenofibrate is able to reduce apo B levels, primarily as a result of reduced synthesis and secretion of TG, and not by directly influencing apo B production.45

Effects on nonlipid parameters

Negative_regulation (inhibiting) of reductase in bile associated with bile
12) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.98 Pain Relevance 0.08
On the contrary, Akira Endo searched for microbial metabolites that would inhibit HMG-CoA reductase, the rate-limiting enzyme in the synthesis of cholesterol and finally, Michael Brown and Joseph Goldstein published a remarkable series of elegant and insightful papers in the 70s and 80s.
Negative_regulation (inhibit) of reductase
13) Confidence 0.01 Published 2008 Journal Current Cardiology Reviews Section Abstract Doc Link PMC2774586 Disease Relevance 0.62 Pain Relevance 0.10
In 1971, Akira Endo started a project to search the microbial metabolites that would inhibit HMG-CoA reductase, the rate-limiting enzyme in the synthesis of cholesterol, with the intent that the suppression of the de novo cholesterol synthesis in the body by inhibiting HMG-CoA reductase would reduce plasma cholesterol in humans.
Negative_regulation (inhibiting) of reductase in plasma
14) Confidence 0.01 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774586 Disease Relevance 0.76 Pain Relevance 0.07
specifically inhibited NADH cytochrome c reductase activity in a dose-dependent
Negative_regulation (inhibited) of reductase
15) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.18 Pain Relevance 0
Guidelines based on evidence from randomized controlled trails recommend that aspirin, beta-adrenergic blockers, angiotensin-converting enzyme (ACE) inhibitors, and hydroxyl methyl glutarate coenzyme A reductase inhibitors (statins) be used in all patients with symptomatic chronic stable angina or asymptomatic survivors of acute myocardial infarction and following percutaneous coronary intervention or coronary bypass surgery for secondary prevention of myocardial infarction, stroke and death.1–4 It has been hypothesized that if used collectively these agents could reduce long term risk of cardiovascular events and mortality by as much as 75%.5 However the actual impact depends on the extent to which they are used in practice.6–8
Negative_regulation (inhibitors) of reductase associated with aspirin, angina, stroke, death and myocardial infarction
16) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788593 Disease Relevance 0.66 Pain Relevance 0.23
By contrast, our observation of lack of such correlations in brains with schizophrenia point to a disturbance of redox coupling mechanisms in the antioxidant defense system, possibly resulting from a decreased level of glutathione (GSH) and age-related decreases of oxidized GSH and glutathione reductase activities.
Negative_regulation (decreases) of reductase in brains associated with schizophrenia
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2831068 Disease Relevance 0.63 Pain Relevance 0
By contrast, lack of such correlations in brains of SZ patients point to a disturbance of redox coupling mechanisms in the AODS, possibly resulting from a decreased level of glutathione (GSH) as well as age-related decreases of oxidized GSH and glutathione reductase activities.
Negative_regulation (decreases) of reductase in brains associated with schizophrenia
18) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2831068 Disease Relevance 0.70 Pain Relevance 0
Statins are a broadly used group of cholesterol-lowering agents that act by inhibiting the enzyme 3-hydroxy 3-methylglutaryl CoA (HMG CoA) reductase, which catalyzes the rate-limiting step in cholesterol biosynthesis [299,300]; therefore, statins reduce the concentration of downstream metabolic by-products including mevalonate, which in turn leads to increased LDL-receptor expression in hepatocytes and to increased LDL-C uptake from the circulation.
Negative_regulation (inhibiting) of reductase in hepatocytes
19) Confidence 0.00 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.97 Pain Relevance 0

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