INT19185

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Context Info
Confidence 0.51
First Reported 1991
Last Reported 2011
Negated 1
Speculated 6
Reported most in Body
Documents 80
Total Number 86
Disease Relevance 61.32
Pain Relevance 8.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 27
lymphocytes 6
B cells 4
thymus 3
NK cells 3
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 458 100.00 Very High Very High Very High
fibrosis 48 99.48 Very High Very High Very High
Inflammation 526 99.40 Very High Very High Very High
Arthritis 129 99.20 Very High Very High Very High
Central nervous system 116 98.44 Very High Very High Very High
Prostatitis 28 98.36 Very High Very High Very High
Kappa opioid receptor 8 98.04 Very High Very High Very High
Demyelination 136 97.84 Very High Very High Very High
Inflammatory response 58 97.72 Very High Very High Very High
tolerance 72 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 2050 100.00 Very High Very High Very High
Mycobacterial Infection 10 100.00 Very High Very High Very High
Toxicity 83 99.90 Very High Very High Very High
Asthma 189 99.84 Very High Very High Very High
Lymphopenia 118 99.84 Very High Very High Very High
Frailty 104 99.84 Very High Very High Very High
INFLAMMATION 592 99.76 Very High Very High Very High
Targeted Disruption 80 99.72 Very High Very High Very High
Sarcoma 6 99.70 Very High Very High Very High
Cancer 1081 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These animals displayed a modest reduction in thymus cellularity and CD4(+) cell ratio, parallel to a slight increase in immature CD4(+)CD8(+) lymphocytes.
Negative_regulation (reduction) of CD4 in lymphocytes
1) Confidence 0.51 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12507774 Disease Relevance 0.17 Pain Relevance 0.53
The atrophy of the thymus was mainly due to a reduction of immature CD4+CD8+ DP.
Negative_regulation (reduction) of CD4 in thymus associated with frailty
2) Confidence 0.49 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 2.72 Pain Relevance 0.04
This reduction was associated with a loss of CD4+CD8+ DP cells (Fig. 7D).
Negative_regulation (loss) of CD4 in DP cells
3) Confidence 0.49 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 1.70 Pain Relevance 0
Close immunologic monitoring revealed a transient, selective depletion of CD4+ T cells after each infusion.
Negative_regulation (depletion) of CD4 in T cells
4) Confidence 0.43 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 2025306 Disease Relevance 0.47 Pain Relevance 0.28
Transfer activity was lost when cells were depleted of CD4(+) or CD25(+) subpopulations.
Negative_regulation (depleted) of CD4
5) Confidence 0.43 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15879089 Disease Relevance 0.39 Pain Relevance 0.14
It is tempting to propose here that the higher decrease in CD4+ and CD8+ populations on the thymus (associated with the comparatively larger stress-period, i.e. larger thymic-involution), would counteract the effect of the increased peripheral demand of T cells from thymus for these two cell subsets.
Negative_regulation (decrease) of CD4 in T cells associated with stress
6) Confidence 0.42 Published 2001 Journal BMC Immunol Section Body Doc Link PMC37547 Disease Relevance 0.57 Pain Relevance 0
Our experience with Chikungunya also showed lymphopenia with a decrease in the CD4 lymphocyte count level.
Negative_regulation (decrease) of CD4 in lymphocyte associated with lymphopenia
7) Confidence 0.41 Published 2010 Journal Cases J Section Body Doc Link PMC2823716 Disease Relevance 1.68 Pain Relevance 0.03
These time points allowed us to focus on the induction of ACAID, particularly where the marked suppression of CD4+ proliferation was observed around day 12.
Negative_regulation (suppression) of CD4
8) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.13 Pain Relevance 0
Comparison of these respective peaks on day 12 to subsequent time points following immunization then indicates a decrease in CD4+ and CD8+ T cell populations.
Negative_regulation (decrease) of CD4 in T cell associated with immunization
9) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.39 Pain Relevance 0
It is more likely that these ACAID-induced Treg cells suppress CTL by an indirect means, e.g., by inhibiting helper CD4+ T cell function, which is important in promoting CD8+ T cell differentiation and effector activity.
Negative_regulation (inhibiting) of CD4 in T cell
10) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.13 Pain Relevance 0
FACS analysis on the blood 2 days after challenge showed that the CD3+/CD4+ cell population of the total CD3 population was between 0–0.23% in mice receiving GK1.5 compared to approximately 60% in non-depleted mice, indicating a very efficient depletion of the CD4+ T cell subset in treated animals (Fig. 5A) which was maintained throughout the infection period.
Negative_regulation (depletion) of CD4 in T cell associated with infection
11) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.46 Pain Relevance 0
Interestingly, synovial fluid-derived CD4+CD28null T cells from all investigated patients showed specificity for these antigens (Figure 3, lower panel).
Spec (investigated) Negative_regulation (derived) of CD4 in T cells
12) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212553 Disease Relevance 0.44 Pain Relevance 0.03
To determine whether the blocking effect of MR1 on HNT CD4+ T cell proliferation was driven by lymphopenia and/or the HA antigen, we performed adoptive transfer experiments in lymphopenic MR1 treated BALB/c mice.
Spec (whether) Negative_regulation (effect) of CD4 in T cell associated with lymphopenia
13) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.21 Pain Relevance 0
Administration of Elocalcitol, at normocalcemic doses, for 2 wk in already established EAP significantly inhibits the intraprostatic cell infiltrate, leading to a profound reduction in the number of CD4(+) and CD8(+) T cells, B cells, macrophages, dendritic cells, and I-A(g7)-positive cells.
Negative_regulation (reduction) of CD4 in dendritic cells associated with prostatitis
14) Confidence 0.37 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17142748 Disease Relevance 0.85 Pain Relevance 0.34
Lethal infection with WR strain resulted in fewer lymphocytes and an altered phenotype of T cells in the lung compared to non-lethal infection and uninfected controls, and induced severe thymus atrophy with a marked reduction of CD4 and CD8 double positive (DP) T cells.


Negative_regulation (reduction) of CD4 in thymus associated with frailty, sprains and strains and infection
15) Confidence 0.36 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 2.01 Pain Relevance 0
Severe thymus atrophy with a reduction of CD4 and CD8 double positive T cells was also observed in the lethal infection.


Negative_regulation (reduction) of CD4 in thymus associated with frailty and infection
16) Confidence 0.36 Published 2007 Journal Virol J Section Abstract Doc Link PMC1810241 Disease Relevance 1.75 Pain Relevance 0
The decrease of CD4+ cells together with high in vitro secretion of TNF?
Negative_regulation (decrease) of CD4
17) Confidence 0.36 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 1.27 Pain Relevance 0.05
The degree of the decrease of CD4+CD8+ DP cells in the non-lethal infection was not as dramatic as in the lethal infection.
Negative_regulation (decrease) of CD4 in DP cells associated with infection
18) Confidence 0.36 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 1.64 Pain Relevance 0
Hyam Levitsky (Sidney Kimmel Comprehensive Cancer Center, John Hopkins School of Medicine, Baltimore, MD) talked about the: "Visualization of tumor antigen specific CD4+ T cell suppression".
Negative_regulation (suppression) of CD4 in T cell associated with cancer
19) Confidence 0.35 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.25 Pain Relevance 0
T cells (**p < .01) and IgE+/B220+ B cells (**p < .01) in BALF and lung tissues significantly were decreased and CD4+/CD8?
Negative_regulation (decreased) of CD4 in B cells
20) Confidence 0.33 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.23 Pain Relevance 0.07

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