INT19188

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 2.97
Pain Relevance 4.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neural 2
urinary bladder 1
peripheral nerves 1
Igh-6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 28 99.62 Very High Very High Very High
opioid receptor 8 98.60 Very High Very High Very High
substance P 8 98.60 Very High Very High Very High
Neuropeptide 2 98.10 Very High Very High Very High
antagonist 4 97.32 Very High Very High Very High
interstitial cystitis 2 97.00 Very High Very High Very High
qutenza 12 96.78 Very High Very High Very High
Enkephalin 4 94.60 High High
Dorsal horn 3 93.32 High High
Pain 1 87.36 High High
Disease Link Frequency Relevance Heat
Renal Disease 2 100.00 Very High Very High Very High
Neuropathic Pain 3 97.28 Very High Very High Very High
Interstitial Cystitis 2 97.00 Very High Very High Very High
Autoimmune Disease 1 93.28 High High
Infection 1 92.36 High High
Disease 2 88.40 High High
Immunization 3 88.28 High High
Increased Venous Pressure Under Development 1 87.32 High High
Coronary Heart Disease 1 86.72 High High
Adverse Drug Reaction 1 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When OR-689.2.4 conjugated to Sepharose was incubated with the partially purified opioid receptor complex, labeled with 125I, a 35,000-dalton protein was specifically bound by the immunoglobulin.
immunoglobulin Binding (bound) of associated with opioid receptor
1) Confidence 0.48 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2999128 Disease Relevance 0 Pain Relevance 0.62
The 125I-labeled immunoglobulin specifically bound to neural membranes with a Kd of 1.3 nM and a maximal number of binding sites of 41.8 fmol/0.25 mg of membrane protein.
immunoglobulin Binding (bound) of in neural
2) Confidence 0.48 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2999128 Disease Relevance 0 Pain Relevance 0.74
The purified immunoglobulin inhibited the binding of [3H]dihydromorphine in a titrable, saturable, and reversible manner, as well as the binding of the delta-ligand [3H][D-Ala2,D-Leu5]enkephalin, the kappa-ligand [3H] ethylketocyclazocine, and 3H-labeled antagonists.
immunoglobulin Binding (binding) of associated with antagonist and enkephalin
3) Confidence 0.37 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2999128 Disease Relevance 0 Pain Relevance 0.66
In addition to blocking the binding of opioids to membranes, the immunoglobulin could also displace bound [3H]dihydromorphine from neural membranes.
immunoglobulin Binding (bound) of in neural associated with opioid
4) Confidence 0.36 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2999128 Disease Relevance 0 Pain Relevance 0.75
Adverse events associated with intravenous immunoglobulin therapy.
immunoglobulin Binding (associated) of
5) Confidence 0.31 Published 2006 Journal Int. Immunopharmacol. Section Title Doc Link 16504916 Disease Relevance 1.03 Pain Relevance 0.08
[Current pathogenetic data on mesangial glomerulonephritis with immunoglobulin A deposits].
immunoglobulin Binding (glomerulonephritis) of associated with renal disease
6) Confidence 0.30 Published 1988 Journal Presse Med Section Title Doc Link 2964596 Disease Relevance 0.19 Pain Relevance 0.08
Immunoblots revealed IgM reactivity to a single 41 kDa protein until 360 days, when reactivity to a 60 kDa protein emerged.
IgM Binding (reactivity) of
7) Confidence 0.30 Published 1990 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 2138431 Disease Relevance 1.08 Pain Relevance 0.22
In this study we show that capsaicin treatment, which is known to decrease the levels of neuropeptides of sensory origin, has a time-dependent effect on both antibody levels in vivo as well as the formation of immunoglobulin in vitro.
immunoglobulin Binding (formation) of associated with qutenza and neuropeptide
8) Confidence 0.14 Published 1991 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2026471 Disease Relevance 0.23 Pain Relevance 0.78
In vivo binding of immunoglobulin and complement to elastic structures in urinary bladder vascular walls in interstitial cystitis: demonstration by immunoelectron microscopy.
immunoglobulin Binding (binding) of in urinary bladder associated with interstitial cystitis
9) Confidence 0.13 Published 1987 Journal Clin. Immunol. Immunopathol. Section Title Doc Link 3549070 Disease Relevance 0.18 Pain Relevance 0.22
Quenching was also obtained with the C-terminal part of o-CRF (range 0.002-0.1 microM), which indicates that both CRF antisera contain an immunoglobulin which recognizes determinants on CRF as well as on SP.
immunoglobulin Binding (recognizes) of associated with substance p
10) Confidence 0.05 Published 1986 Journal Brain Res. Section Abstract Doc Link 2433002 Disease Relevance 0 Pain Relevance 0.66
It is suggested that immunohistochemical studies of skin biopsies provide a simple effective method of detecting immunoglobulin binding to peripheral nerves in patients suspected of having an autoimmune neuropathy.
immunoglobulin Binding (binding) of in peripheral nerves associated with neuropathic pain
11) Confidence 0.02 Published 1987 Journal Neurology Section Abstract Doc Link 3027613 Disease Relevance 0.26 Pain Relevance 0.09

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