INT192059

From wiki-pain
Revision as of 04:27, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 1.53
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hoxa10) DNA binding (Hoxa10)
Anatomy Link Frequency
endometrium 4
Hoxa10 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 1 86.40 High High
abdominal pain 1 55.52 Quite High
cva 6 22.72 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
endometriosis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 18 85.04 High High
Leukemia 30 83.60 Quite High
Hyperplasia 6 81.12 Quite High
Acute Myeloid Leukemia 24 81.04 Quite High
Reprotox - General 1 3 79.16 Quite High
Syndrome 23 78.20 Quite High
Myeloid Leukemia 6 73.52 Quite High
Abdominal Pain 1 55.52 Quite High
Focal Segmental Glomerulosclerosis 1 41.24 Quite Low
Proteinuria 1 34.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that a similar regulation occurs with HOXA10 and MEIS1 cofactor in the endometrium.
HOXA10 Spec (likely) Binding (occurs) of in endometrium
1) Confidence 0.33 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.28 Pain Relevance 0
The expression pattern of MEIS1, its contribution to pinopode formation in mouse and its effect on Itgb3 expression suggest that the effects of MEIS1 on endometrial function occur through affecting the affinity and specificity of HOXA10–DNA interactions, leading to the regulation of downstream targets of HOXA10.
HOXA10 Binding (interactions) of
2) Confidence 0.33 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.16 Pain Relevance 0
PCR primers were designed to amplify HOXA7, HOXA9, HOXA10, HOXA11, HOXA13 (Table 1) and PBX1 coding exons (Table 2).
HOXA10 Binding (amplify) of
3) Confidence 0.27 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1444933 Disease Relevance 0.27 Pain Relevance 0.10
It appeared likely that Itgb3 was not regulated by Hoxa10 monomer, but by a heterodimeric or heterotrimeric transcription complex containing Meis1.
Hoxa10 monomer Binding (complex) of
4) Confidence 0.26 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.15 Pain Relevance 0
3, a transcriptional target of HOXA10 and an important factor in early embryo-endometrium interactions (P = 0.006).
HOXA10 Binding (target) of in endometrium
5) Confidence 0.26 Published 2008 Journal Human Reproduction (Oxford, England) Section Abstract Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Ablation of the PBX cofactor half-site results in a loss of HOXA10–PBX2 binding to the EMX2 probe, suggesting the importance of the PBX2/HOXA10 protein–protein interaction in endometrium for high affinity HOXA10 binding to its target genes (Sarno et al., 2005).
HOXA10 Binding (binding) of in endometrium
6) Confidence 0.26 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.34 Pain Relevance 0
Ablation of the PBX cofactor half-site results in a loss of HOXA10–PBX2 binding to the EMX2 probe, suggesting the importance of the PBX2/HOXA10 protein–protein interaction in endometrium for high affinity HOXA10 binding to its target genes (Sarno et al., 2005).
HOXA10 Binding (binding) of in endometrium
7) Confidence 0.25 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.34 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox