INT19218

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Context Info
Confidence 0.41
First Reported 1991
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 9.21
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cells 5
regulatory T cells 4
natural killer cell 2
plasma 1
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 54 97.86 Very High Very High Very High
shoulder pain 1 97.12 Very High Very High Very High
Inflammatory response 1 92.96 High High
corticosteroid 9 88.76 High High
methotrexate 6 88.04 High High
cytokine 51 87.04 High High
addiction 12 59.68 Quite High
Inflammation 53 53.60 Quite High
tolerance 16 22.40 Low Low
Arthritis 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 185 100.00 Very High Very High Very High
Disease 50 100.00 Very High Very High Very High
Fever 35 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 513 99.84 Very High Very High Very High
Brachial Plexus Neuritis 9 99.22 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 4 99.12 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 5 98.88 Very High Very High Very High
Viremia 16 98.40 Very High Very High Very High
Shoulder Pain 1 97.12 Very High Very High Very High
Cold Sores 203 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most (5/6) NA patients had decreased CD3 values and increased CD4/CD8 ratios due to a decreased of the CD8 subset.
Negative_regulation (decreased) of Positive_regulation (increased) of CD4 associated with brachial plexus neuritis
1) Confidence 0.41 Published 1991 Journal Acta Neurol. Scand. Section Abstract Doc Link 2031452 Disease Relevance 0.74 Pain Relevance 0.10
In Kawasaki disease, Furuno et al. found that during the active phase of the disease, the number of circulating CD4+CD25high regulatory T cells is reduced compared to patients with infectious causes of febrile illness, whose CD4+CD25high regulatory T cell numbers are higher than in healthy subjects.
Negative_regulation (reduced) of Positive_regulation (regulatory T cells) of CD4 in regulatory T cell associated with mucocutaneous lymph node syndrome, fever and disease
2) Confidence 0.41 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.18 Pain Relevance 0.09
In defervesce phase of the disease, the number of CD4+CD25high regulatory T cells in patients with Kawasaki disease increases to/or above normal levels, while CD4+CD25high regulatory T cells in patients with infectious febrile disease decrease to normal levels [138].
Negative_regulation (decrease) of Positive_regulation (regulatory T cells) of CD4 in regulatory T cells associated with mucocutaneous lymph node syndrome, fever and disease
3) Confidence 0.41 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.27 Pain Relevance 0.07
In this study, short-term administration of leflunomide to HIV-1 infected participants not receiving antiretroviral therapy was overall well tolerated and led to decreases in CD4 T cell cycling and CD8 T cell activation as well as decreases in expression of both CCR5 and CXCR4 without any significant effects on T cell counts or plasma HIV-1 levels.
Negative_regulation (decreases) of in plasma Positive_regulation (activation) of CD4 in T cell associated with acquired immune deficiency syndrome or hiv infection and leflunomide
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914784 Disease Relevance 0.48 Pain Relevance 0.15
Increases in CD4 cell count/percentage and decreases in HIV RNA levels signify a response to ART.
Negative_regulation (decreases) of Positive_regulation (Increases) of CD4 associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.39 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701488 Disease Relevance 0.76 Pain Relevance 0.03
Hence, the functional relevance of Env (and Gag) specific CD4+ and CD8+ T cells in setting of vaccination for prevention of infection needs to be further explored.
Negative_regulation (explored) of Positive_regulation (relevance) of CD4 in T cells associated with infection
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981570 Disease Relevance 0.70 Pain Relevance 0.03
Antigen-specific T cell responses were examined in more detail by ICS to more accurately dissect the involvement of CD4+ and CD8+ T cells (?
Spec (examined) Negative_regulation (dissect) of Positive_regulation (involvement) of CD4 in T cells
7) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 0.87 Pain Relevance 0.04
During initial treatment with raltegravir, rapid reduction of viral load and increase in CD4 cell count could result in immune reconstitution syndrome in some patients.
Negative_regulation (reduction) of Positive_regulation (increase) of CD4 associated with immune reconstitution inflammatory syndrome
8) Confidence 0.24 Published 2010 Journal Core evidence Section Body Doc Link PMC2899791 Disease Relevance 0.91 Pain Relevance 0.05
By comparison, the circulating CD4+ T cell concentration transiently decreased only about 25%, soon after the peak in viremia, while the circulating natural killer cell concentration remained elevated due to the IL-2 administration, and unchanged throughout the eight-week DTI.
Negative_regulation (decreased) of Positive_regulation (circulating) of CD4 in natural killer cell associated with viremia
9) Confidence 0.17 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1783674 Disease Relevance 0.87 Pain Relevance 0
Our patients were severely immunossuppressed (median CD4 39.5?
Negative_regulation (immunossuppressed) of Positive_regulation (median) of CD4
10) Confidence 0.17 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2929489 Disease Relevance 1.44 Pain Relevance 0.14

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