INT192409

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 102
Total Number 107
Disease Relevance 64.66
Pain Relevance 18.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 31
lung 8
macrophages 6
sciatic nerve 6
NK cells 5
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1812 100.00 Very High Very High Very High
Inflammation 1115 100.00 Very High Very High Very High
Arthritis 303 99.92 Very High Very High Very High
endometriosis 174 99.88 Very High Very High Very High
metalloproteinase 93 99.78 Very High Very High Very High
Dopamine 10 99.28 Very High Very High Very High
fibrosis 71 99.20 Very High Very High Very High
aspirin 83 98.40 Very High Very High Very High
Sciatic nerve 156 98.22 Very High Very High Very High
cINOD 38 98.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1230 100.00 Very High Very High Very High
Infection 973 100.00 Very High Very High Very High
Hypersensitivity Pneumonitis 140 100.00 Very High Very High Very High
Injury 90 100.00 Very High Very High Very High
Chlamydia Infection 544 99.92 Very High Very High Very High
Arthritis 210 99.92 Very High Very High Very High
Polyradiculoneuropathy 22 99.92 Very High Very High Very High
Hepatotoxicity 17 99.92 Very High Very High Very High
Endometriosis 224 99.88 Very High Very High Very High
Cold Sores 368 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Due to immune restoration, an inflammatory response against infectious and non-infectious antigens (LPS) is mounted leading to noticeable 'paradoxical worsening' [43-45], with a shift toward a Th1 receptor profile, which increases the levels of IFN-?
Positive_regulation (increases) of Gene_expression (levels) of IFN associated with inflammatory response
1) Confidence 0.67 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 1.18 Pain Relevance 0.16
upregulates the production of proinflammatory cytokines IFN-?
Positive_regulation (upregulates) of Gene_expression (production) of IFN associated with cytokine
2) Confidence 0.67 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.27 Pain Relevance 0.19
An effective intranasal conjugate pneumococcal vaccine using interleukin-12 (IL-12) as a mucosal adjuvant induced protection and increased expression of lung and splenic IFN-?
Positive_regulation (increased) of Gene_expression (expression) of IFN in lung
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.96 Pain Relevance 0.24
In the airways of asthmatic patients TH1 cells, increased levels of IFN-?
Positive_regulation (increased) of Gene_expression (levels) of IFN associated with asthma
4) Confidence 0.67 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.62 Pain Relevance 0.13
A recent paper by Schwarz et al. showed that wire-mediated arterial injury induced local and systemic expression of IFN-?
Positive_regulation (induced) of Gene_expression (expression) of IFN associated with injury
5) Confidence 0.67 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.67 Pain Relevance 0.18
Moreover, peripheral blood mononuclear cells (PBMCs) from esophagopathy patients produce high levels of inflammatory cytokines such as IFN-?
Positive_regulation (levels) of Gene_expression (produce) of IFN in blood associated with inflammation and cytokine
6) Confidence 0.67 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.98 Pain Relevance 0.10
Differentiation of monocytes to dendritic cells (DC) increases surface expression of prion protein [37] and IFN-?
Positive_regulation (increases) of Gene_expression (expression) of IFN in dendritic cells
7) Confidence 0.67 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1590031 Disease Relevance 0.25 Pain Relevance 0
Macrophages and sciatic nerve tissue in Tg+ sick mice exhibit a markedly pro-inflammatory gene expression profile, as evident by upregulated expression of FasL, IFN-?
Positive_regulation (upregulated) of Gene_expression (expression) of IFN in sciatic nerve associated with inflammation and sciatic nerve
8) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.28 Pain Relevance 0.62
This was directly tested here by constitutive overexpression of IFN-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of IFN
9) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.40 Pain Relevance 0.15
The approach of Kumar and colleagues (2003) aims to overcome IFN-?
Positive_regulation (overcome) of Gene_expression (overcome) of IFN
10) Confidence 0.49 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673971 Disease Relevance 0.82 Pain Relevance 0.24
production are associated with recurrent infections, production of adequate levels of IFN-?
Positive_regulation (levels) of Gene_expression (production) of IFN associated with infection
11) Confidence 0.49 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 0.69 Pain Relevance 0.12
Very recently, we reported that CD4+CD25+ regulatory T (Treg) cells attenuate SR-induced HP by suppressing IFN-?
Positive_regulation (induced) of Gene_expression (suppressing) of IFN associated with hypersensitivity pneumonitis
12) Confidence 0.49 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.46 Pain Relevance 0
-producing CD4+ and CD8+ T cells in the lungs and loss of NKT cell-mediated suppression of IFN-?
Positive_regulation (mediated) of Gene_expression (suppression) of IFN in lungs
13) Confidence 0.49 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.82 Pain Relevance 0.07
An autoimmune mechanism in IP is supported by higher levels of IFN?
Positive_regulation (supported) of Gene_expression (levels) of IFN associated with polyradiculoneuropathy
14) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2841649 Disease Relevance 1.13 Pain Relevance 0.24
In fact, LDR0723 favoured production of IL-12 rather than of IFN-?
Positive_regulation (fact) of Gene_expression (favoured) of IFN
15) Confidence 0.49 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.54 Pain Relevance 0.18
Moreover, IL-12, IFN-?
Positive_regulation (Moreover) of Gene_expression (Moreover) of IFN
16) Confidence 0.49 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.60 Pain Relevance 0.27
IL-12 has an essential role in Th1 development, stimulating activated T cells and NK cells to maximally produce IFN-?
Positive_regulation (activated) of Gene_expression (produce) of IFN in NK cells
17) Confidence 0.49 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.41 Pain Relevance 0.15
For both of these vaccines, protection was found to be dependent upon CD4+ T cells producing IFN-?
Positive_regulation (upon) of Gene_expression (producing) of IFN in T cells
18) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.59 Pain Relevance 0
An effective intranasal conjugate pneumococcal vaccine using interleukin-12 (IL-12) as a mucosal adjuvant induced protection and increased expression of lung and splenic IFN-?
Positive_regulation (increased) of Gene_expression (expression) of IFN in lung
19) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.96 Pain Relevance 0.24
IL-12, a crucial cytokine for DC-mediated induction of Th1 cell differentiation, is also known as a T cell stimulating factor, which stimulates the production of IFN-?
Positive_regulation (stimulates) of Gene_expression (production) of IFN in Th1 cell associated with cytokine
20) Confidence 0.49 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.56 Pain Relevance 0.56

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