INT192808

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 7.31
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
Anatomy Link Frequency
parathyroid 12
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 98.86 Very High Very High Very High
Thoracotomy 6 73.92 Quite High
depression 3 73.20 Quite High
Pain 34 71.40 Quite High
imagery 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
drug abuse 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Paresthesia 2 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypocalcemia 27 99.72 Very High Very High Very High
Metastasis 55 99.36 Very High Very High Very High
Hypercalcemia 70 96.76 Very High Very High Very High
Pleurisy 2 96.00 Very High Very High Very High
Cardiovascular Disease 4 95.76 Very High Very High Very High
Hypertension 6 93.84 High High
Diabetes Mellitus 10 92.72 High High
Nephrotoxicity 3 92.00 High High
Bone Cancer 6 91.36 High High
Osteoporosis 8 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Magnesium affects the function of the parathyroid glands [14] where it acts as an agonist at the calcium-sensing receptors and, like calcium, can decrease parathyroid hormone (PTH) secretion [15].
Negative_regulation (decrease) of Localization (secretion) of parathyroid hormone in parathyroid associated with agonist
1) Confidence 0.59 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2908636 Disease Relevance 0.91 Pain Relevance 0.05
Cinacalcet is a calcimimetic, which reduces parathyroid hormone secretion by binding to the calcium-sensing receptor on parathyroid cells, increasing the sensitivity of these cells to extracellular calcium concentrations [15, 30, 31].
Negative_regulation (reduces) of Localization (secretion) of parathyroid hormone in parathyroid
2) Confidence 0.58 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 1.09 Pain Relevance 0
Cinacalcet (Sensipar®, Amgen, USA), a type II calcimimetic, allosterically increases the sensitivity of the calcium-sensing receptor, lowering the threshold for activation, and thereby decreasing secretion of parathyroid hormone (PTH) [1].
Negative_regulation (decreasing) of Localization (secretion) of parathyroid hormone in parathyroid
3) Confidence 0.44 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2907400 Disease Relevance 1.00 Pain Relevance 0.14
Magnesium affects the function of the parathyroid glands [14] where it acts as an agonist at the calcium-sensing receptors and, like calcium, can decrease parathyroid hormone (PTH) secretion [15].
Negative_regulation (decrease) of Localization (secretion) of PTH in parathyroid associated with agonist
4) Confidence 0.43 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2908636 Disease Relevance 0.91 Pain Relevance 0.05
In contrast, radiofrequency ablation (RFA) of the lesion, although complicated by an episode of severe pleuritis, was very successful in achieving biochemical remission, with serum PTH concentrations decreasing from 265 pmol/l to <1 pmol/l (Fig. 2), suggesting that the metastasis targeted with RFA was the only source of PTH secretion.
Negative_regulation (source) of Localization (secretion) of PTH associated with pleurisy and metastasis
5) Confidence 0.43 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.96 Pain Relevance 0.04
Hypomagnaesemic induced hypocalcaemia is caused by inhibition of parathyroid hormone secretion, impaired calcium release from the bones and low tissue responses to PTH due to low magnesium levels.
Negative_regulation (inhibition) of Localization (secretion) of parathyroid hormone in parathyroid associated with hypocalcemia
6) Confidence 0.39 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475608 Disease Relevance 1.44 Pain Relevance 0.04
Cinacalcet (Sensipar®, Amgen, USA), a type II calcimimetic, allosterically increases the sensitivity of the calcium-sensing receptor, lowering the threshold for activation, and thereby decreasing secretion of parathyroid hormone (PTH) [1].
Negative_regulation (decreasing) of Localization (secretion) of PTH in parathyroid
7) Confidence 0.32 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2907400 Disease Relevance 1.01 Pain Relevance 0.14

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