INT192856

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2r1a) chromosome segregation (Ppp2r1a) chromosome (Ppp2r1a)
cytoplasm (Ppp2r1a)
Anatomy Link Frequency
brain 2
microglia 2
Ppp2r1a (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 5 86.64 High High
Migraine 1 74.40 Quite High
Central nervous system 33 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
glial activation 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 36 87.84 High High
Ataxia 33 77.44 Quite High
Migraine With Aura 1 76.00 Quite High
Infection 61 64.56 Quite High
Leukemia 3 50.00 Quite Low
Cerebellar Ataxia 3 42.12 Quite Low
Spinocerebellar Ataxia Type 2 17 38.80 Quite Low
Ocular Toxicity (including Many Sub-types) 2 26.48 Quite Low
Neurodegenerative Disease 5 26.08 Quite Low
Ophthalmoplegia 1 23.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gag immunoblotting (figure 1C, lower panel) showed the presence of glyco-gag and pr65gag expression in all FrCasE- and Fr57E-infected microglia, at levels that did not differ significantly between equivalent cell extracts.
Regulation (presence) of Gene_expression (expression) of pr65gag in microglia
1) Confidence 0.16 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.06 Pain Relevance 0
SCA12 is caused by a CAG repeat expansion that is not transcribed to polyglutamine and is speculated to affect the expression of the gene PPP2R2B, which encodes a brain-specific regulatory subunit of protein phosphatase PP2A (Holmes et al 1999).
Regulation (affect) of Gene_expression (expression) of phosphatase PP2A in brain
2) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.55 Pain Relevance 0.12

General Comments

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