INT192865

Context Info Confidence 0.07 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.67 Pain Relevance 0.08

isomerase activity (Pdia3) endoplasmic reticulum (Pdia3) enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1) cytoplasm (Esr1)

Esr1 (Mus musculus) Pdia3 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 33 79.28 Spinal cord 3 5.00 anesthesia 1 5.00 Inflammation 1 5.00 glial activation 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Stress 40 99.96 Infection 61 78.84 Leukemia 3 50.00 Disease 8 5.00 Neurodegenerative Disease 3 5.00 Death 1 5.00 Necrosis 1 5.00 Subacute Sclerosing Panencephalitis 1 5.00 Skin Cancer 1 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Four of these genes, BiP, CHOP, Calreticulin and grp58, are known to be specifically associated with ER stress.

ER Binding (associated) of grp58 associated with stress

1) Confidence 0.07 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.67 Pain Relevance 0.08

General Comments

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