INT19331

Context Info Confidence 0.49 First Reported 1987 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 12 Total Number 12 Disease Relevance 7.72 Pain Relevance 3.28

plasma membrane (HLA-A)

Anatomy Link Frequency B35 1 bowel 1 optic 1 cytotoxic T-lymphocytes 1 T cells 1 HLA-A (Homo sapiens)

Pain Link Frequency Relevance Heat Neuritis 11 99.84 cINOD 7 99.84 Multiple sclerosis 10 98.30 Inflammation 57 98.16 cytokine 44 97.64 Arthritis 9 96.80 spinal inflammation 15 95.68 Inflammatory stimuli 10 94.04 Angina 7 81.28 Inflammatory response 2 57.92

Disease Link Frequency Relevance Heat Optic Neuritis 11 99.84 Dengue Hemorrhagic Fever 139 99.20 Mucocutaneous Lymph Node Syndrome 83 98.64 Demyelinating Disease 11 98.30 INFLAMMATION 67 98.16 Seronegative Spondarthritis 6 97.16 Uveitis 4 96.42 Low Back Pain 15 95.68 Syndrome 24 94.72 Inflammatory Bowel Disease 2 93.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The prevalence of HLA-A, B, C and DR antigens was determined and compared in 94 patients with reactive arthritis, 54 patients with ankylosing spondylitis (AS), 37 patients with inflammatory bowel disease (IBD) and in 1,010 apparently normal blood donors.

Positive_regulation (prevalence) of HLA-A in bowel associated with seronegative spondarthritis, spinal inflammation, inflammatory bowel disease, inflammation and arthritis

1) Confidence 0.49 Published 1987 Journal J. Rheumatol. Section Abstract Doc Link 3498033 Disease Relevance 1.04 Pain Relevance 0.60

Patients with PIL demonstrate an increased prevalence of the HLA-A1, -A28, -B44, -DR6, and -DR7 antigens.

Positive_regulation (increased) of HLA-A1

2) Confidence 0.46 Published 1991 Journal J. Child Neurol. Section Abstract Doc Link 2045632 Disease Relevance 0.60 Pain Relevance 0.22

HLA-DM, -DO (peptide loading), HLA-DP, -DQ, -DR (antigen presentation), granzyme B, H, perforin and FCGR3A (CD16) (cytotoxicity) displayed increased expression, as did CD8, a marker of cytotoxic T-lymphocytes, while HLA-A and -C expression were not increased by NSAID treatment.

Neg (not) Positive_regulation (increased) of HLA-A in cytotoxic T-lymphocytes associated with cinod

3) Confidence 0.45 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.82 Pain Relevance 0.60

OBJECTIVE: To describe a cohort of patients with pars planitis followed at a single tertiary care institution, determine the frequency of multiple sclerosis and/or optic neuritis in patients with this disorder, and calculate gene frequencies of human leukocyte antigen (HLA) class II alleles in these patients.

Positive_regulation (frequencies) of HLA in optic associated with multiple sclerosis, optic neuritis, uveitis and neuritis

4) Confidence 0.37 Published 1999 Journal Ophthalmology Section Abstract Doc Link 10080220 Disease Relevance 0.37 Pain Relevance 0.15

HLA-B5, B51, B38, B27, and B35 were significantly increased in ON patients compared with control subjects.

Positive_regulation (increased) of HLA in B35 associated with neuritis

5) Confidence 0.31 Published 2005 Journal Eur. J. Neurol. Section Abstract Doc Link 15613143 Disease Relevance 1.19 Pain Relevance 0.97

In the analysis of the polymorphisms of HLA-C alleles, there was a significant increase in the frequency of the HLA-Cw09 allele in the patients with Kawasaki disease compared with the healthy control group (p < 0.04; RR = 2.0).

Positive_regulation (increase) of HLA associated with mucocutaneous lymph node syndrome

6) Confidence 0.28 Published 2007 Journal Pediatr Cardiol Section Body Doc Link PMC2267487 Disease Relevance 0.85 Pain Relevance 0

Patients were also shown to have a significant increase in CD4+ T cells expressing the activation markers CD25 (P < 0.05) and HLA-DR (P < 0.01).

Positive_regulation (activation) of HLA in T cells

7) Confidence 0.25 Published 2002 Journal Acta Physiol. Scand. Section Abstract Doc Link 12354174 Disease Relevance 0.63 Pain Relevance 0.48

With respect to HLA-C alleles, individuals with AS showed an increased frequency of HLA-Cw02.

Positive_regulation (frequency) of HLA

8) Confidence 0.05 Published 2008 Journal J. Clin. Immunol. Section Body Doc Link 18297378 Disease Relevance 0.08 Pain Relevance 0

HLA-ABC was induced majorly (Figure 2A, B) on treatment with pro-inflammatory cytokines.

Positive_regulation (induced) of HLA-ABC associated with inflammation and cytokine

9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.44 Pain Relevance 0.27

As shown in Table 4 and 5, HLA-A*24 increased in frequency among DHF and DSS patients when compared with the control in all 3 sample groups, HCMC 02-03 (DSS: OR?

Positive_regulation (increased) of HLA-A*24 associated with dengue hemorrhagic fever

10) Confidence 0.04 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.41 Pain Relevance 0

The frequencies of HLA-DR4 and HLA-DRw53 were shown to be significantly increased in 231 VKH patients as compared with those in 289 healthy controls (Table 4).

Positive_regulation (increased) of HLA

11) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645903 Disease Relevance 0.29 Pain Relevance 0

Two sets of analyses were performed for each of these three measures (HLA-ABC, CD19, and standardized HLA-ABC) as the dependent variable.

Positive_regulation (standardized) of HLA-ABC

12) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0

General Comments

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