INT193542

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
proximal 2
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 67 99.00 Very High Very High Very High
Sciatic nerve 15 77.44 Quite High
antagonist 8 58.48 Quite High
cytokine 2 56.80 Quite High
bDMF 24 44.56 Quite Low
Nerve growth factor 5 30.24 Quite Low
Hippocampus 14 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 59 99.00 Very High Very High Very High
Nervous System Injury 7 77.72 Quite High
Ganglion Cysts 1 74.96 Quite High
Injury 8 73.12 Quite High
Cognitive Disorder 16 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether anterograde transport of ERK-P is involved in the up-regulation of ERK-P in the proximal stump remains to be clarified.
Regulation (involved) of Regulation (regulation) of ERK in proximal
1) Confidence 0.25 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.23 Pain Relevance 0.07
A functional role for ERK and Akt signaling in EDC and E2-BSA neuroprotection against GCI is suggested by the findings in Fig. 5C (a,b), in which pretreatment with PD98059 or LY294002 markedly attenuated EDC and E2-BSA neuroprotection, as demonstrated by NeuN staining (Fig. 5C,a) and number of NeuN-positive cells (Fig. 5C,b) in the hippocampal CA1 region.
Regulation (role) of Regulation (signaling) of ERK associated with ischemia
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.56 Pain Relevance 0.31

General Comments

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