INT193859

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.85
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 90.64 High High
Inflammatory response 15 36.88 Quite Low
cerebral cortex 2 34.48 Quite Low
cytokine 10 33.60 Quite Low
Hippocampus 33 28.24 Quite Low
cINOD 38 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
Nicotine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 38 100.00 Very High Very High Very High
Disease 299 99.70 Very High Very High Very High
Amyloid Plaque 19 96.08 Very High Very High Very High
Targeted Disruption 56 93.44 High High
INFLAMMATION 68 90.64 High High
Alzheimer's Dementia 21 79.68 Quite High
Skin Cancer 1 77.80 Quite High
Gliosis 3 76.80 Quite High
Increased Venous Pressure Under Development 3 75.28 Quite High
Keratitis 1 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that association between N- and C-terminal domains of PS1 holoprotein occurs prior to endoproteolysis; and following assembly, PS-derived NTF/CTF do not exchange between ?
Negative_regulation (derived) of PS1 Binding (association) of
1) Confidence 0.42 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.07 Pain Relevance 0
-secretase plays an essential role on AD pathogenesis, PS1 inactivation reduces significantly age-dependent A?
Negative_regulation (reduces) of PS1 Binding (inactivation) of associated with disease
2) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.18 Pain Relevance 0.05
E9 mice to a diet high in omega-3 fatty acids, however, neither improved cognition in APPswe/PS1?
Neg (neither) Negative_regulation (improved) of PS1 Neg (neither) Binding (cognition) of associated with cognitive disorder
3) Confidence 0.28 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.60 Pain Relevance 0

General Comments

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