INT19395

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Context Info
Confidence 0.58
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 10.16
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth) extracellular region (Pth) cellular_component (Pth)
Anatomy Link Frequency
parathyroid 14
Pth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 4 95.84 Very High Very High Very High
palliative 1 91.08 High High
fibrosis 6 79.80 Quite High
Pain 17 76.40 Quite High
agonist 1 75.00 Quite High
pruritus 6 27.96 Quite Low
imagery 10 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 109 99.84 Very High Very High Very High
Parathyroid Cancer 10 99.68 Very High Very High Very High
Acidosis 12 99.58 Very High Very High Very High
Increased Venous Pressure Under Development 3 99.16 Very High Very High Very High
Chronic Renal Failure 116 98.32 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 98.12 Very High Very High Very High
Sarcoidosis 26 97.44 Very High Very High Very High
Granuloma 2 95.92 Very High Very High Very High
Osteoporosis 23 95.80 Very High Very High Very High
Renal Tubular Acidosis 3 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence is presented to support the hypothesis that in subjects with parathyroid hyperactivity and Mg++ deficiency, the stimulus of a rise in serum ionic calcium (Ca++), and the resultant inhibition of parathyroid hormone (PTH) secretion, trigger the transfer of Ca++, Mg++ and other ions from the extracellular space into the exchangeable bone compartment.
Negative_regulation (inhibition) of Localization (secretion) of parathyroid hormone in parathyroid associated with attention deficit hyperactivity disorder
1) Confidence 0.58 Published 1991 Journal Med. Hypotheses Section Abstract Doc Link 2056930 Disease Relevance 0.34 Pain Relevance 0.07
Evidence is presented to support the hypothesis that in subjects with parathyroid hyperactivity and Mg++ deficiency, the stimulus of a rise in serum ionic calcium (Ca++), and the resultant inhibition of parathyroid hormone (PTH) secretion, trigger the transfer of Ca++, Mg++ and other ions from the extracellular space into the exchangeable bone compartment.
Negative_regulation (inhibition) of Localization (secretion) of PTH in parathyroid associated with attention deficit hyperactivity disorder
2) Confidence 0.42 Published 1991 Journal Med. Hypotheses Section Abstract Doc Link 2056930 Disease Relevance 0.34 Pain Relevance 0.07
It increases the sensitivity of the CaR to activation by extracellular calcium and thus suppresses PTH release, while simultaneously lowering levels of serum P and Ca, and Ca × P [13,20–23].
Negative_regulation (suppresses) of Localization (release) of PTH
3) Confidence 0.41 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2644631 Disease Relevance 0.06 Pain Relevance 0
Vitamin D analogs, like paricalcitol, have been developed to suppress parathyroid hormone (PTH) secretion without concomitant elevations in the serum calcium or phosphorus levels.
Negative_regulation (suppress) of Localization (secretion) of parathyroid hormone in parathyroid
4) Confidence 0.41 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 1.07 Pain Relevance 0.07
Prior to parathyroid surgery, all patients were administered with calcitriol to decrease secretion of PTH.
Negative_regulation (decrease) of Localization (secretion) of PTH in parathyroid
5) Confidence 0.21 Published 2009 Journal World J Surg Section Body Doc Link PMC2712635 Disease Relevance 0.19 Pain Relevance 0.10
In another study in dialysis patients, correction of the acidosis restored the normal suppression of PTH secretion in response to infused calcium [28].
Negative_regulation (suppression) of Localization (secretion) of PTH associated with acidosis
6) Confidence 0.16 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 1.84 Pain Relevance 0.04
PTH release is inhibited by hypercalcemia and high levels of calcitriol, which explains the suppressed PTH level in sarcoidosis [8].
Negative_regulation (inhibited) of Localization (release) of PTH associated with sarcoidosis and hypercalcemia
7) Confidence 0.12 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2500026 Disease Relevance 2.10 Pain Relevance 0
Cinacalcet modulates (increases the sensitivity of) calcium receptors on the surface of parathyroid cells thereby inhibiting the oversecretion of parathyroid hormone, which characterises HPT.
Negative_regulation (inhibiting) of Localization (oversecretion) of parathyroid hormone in parathyroid associated with hypercalcemia
8) Confidence 0.12 Published 2003 Journal Drugs R D Section Abstract Doc Link 14584963 Disease Relevance 0.94 Pain Relevance 0.08
It is associated with vascular and other soft tissue calcifications.43–49 Moreover, high PTH levels, an increased hyperphosphatemia and calcium X phosphate product are associated with increased mortality rate in patients with ESRD.46 Therefore, therapeutic regimens that can maintain normal serum Ca and P levels, reduce PTH secretion, and correct deficiency of 1?
Negative_regulation (reduce) of Localization (secretion) of PTH associated with chronic renal failure
9) Confidence 0.08 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635909 Disease Relevance 2.08 Pain Relevance 0
The identification of a specific membrane receptor able to bind extracellular calcium on cells of the parathyroid and other tissues has allowed the development of new molecules acting through this receptor to reduce both parathyroid hormone secretion and the rate of parathyroid cell proliferation.
Negative_regulation (reduce) of Localization (secretion) of parathyroid hormone in parathyroid
10) Confidence 0.05 Published 2004 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15013942 Disease Relevance 0.58 Pain Relevance 0.13
Furthermore ET inhibits parathyroid hormone secretion in the parathyroid adenoma cells [18].
Negative_regulation (inhibits) of Localization (secretion) of parathyroid hormone in parathyroid associated with parathyroid cancer
11) Confidence 0.04 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1242236 Disease Relevance 0.62 Pain Relevance 0

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