INT1940

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Context Info
Confidence 0.78
First Reported 1977
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.28
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PIK3C2A) plasma membrane (PIK3C2A) nucleus (PIK3C2A)
cytoplasm (PIK3C2A)
Anatomy Link Frequency
blood 1
liver 1
skeletal muscle cells 1
PIK3C2A (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 4 98.44 Very High Very High Very High
Angina 2 97.92 Very High Very High Very High
anesthesia 1 95.12 Very High Very High Very High
alcohol 2 77.64 Quite High
cva 7 75.12 Quite High
Pain 26 74.80 Quite High
backache 10 74.72 Quite High
Dopamine 6 71.44 Quite High
Thoracotomy 1 71.44 Quite High
Endep 1 66.52 Quite High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 20 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 4 100.00 Very High Very High Very High
Myocardial Infarction 35 99.54 Very High Very High Very High
Syndrome 7 98.84 Very High Very High Very High
Cv Unclassified Under Development 4 98.44 Very High Very High Very High
Rhabdomyolysis 7 98.06 Very High Very High Very High
Cv General 3 Under Development 3 97.92 Very High Very High Very High
Hypercalcemia 15 97.74 Very High Very High Very High
Sudden Death 2 97.28 Very High Very High Very High
Leukocytosis 1 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that severe ischemia before aortic cross-clamping precedes perioperative MI and may contribute to release of CPK into coronary sinus blood.
Localization (release) of CPK in blood associated with ischemia and myocardial infarction
1) Confidence 0.78 Published 1977 Journal Circulation Section Abstract Doc Link 301799 Disease Relevance 1.14 Pain Relevance 0.24
For each pt CKP-p has been evaluated as well as the pre-UCC time (T-pc), the maximum value of released CPK (CPK-max), the incidence of new coronary events such as angina, re-AMI, sudden death detected between the 1st (NEC-I) and the 6th month (NEC-II) after the acute event.
Localization (released) of CPK associated with angina, sudden death and myocardial infarction
2) Confidence 0.78 Published 1987 Journal G Ital Cardiol Section Abstract Doc Link 3653595 Disease Relevance 1.14 Pain Relevance 0.10
For each pt CKP-p has been evaluated as well as the pre-UCC time (T-pc), the maximum value of released CPK (CPK-max), the incidence of new coronary events such as angina, re-AMI, sudden death detected between the 1st (NEC-I) and the 6th month (NEC-II) after the acute event.
Localization (released) of CPK associated with angina, sudden death and myocardial infarction
3) Confidence 0.78 Published 1987 Journal G Ital Cardiol Section Abstract Doc Link 3653595 Disease Relevance 1.14 Pain Relevance 0.10
Laboratory findings were: serum creatinine phosphokinase (CPK) 1895 U/L, lactate dehydrogenase 835 U/L, WBC 14 300/?
Localization (serum creatinine phosphokinase) of CPK
4) Confidence 0.73 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661629 Disease Relevance 0.78 Pain Relevance 0.14
Side effects or complications that are ascribed to the treatment are recorded by the patients, their treating physicians and the research nurses.

4) Serum creatine phosphokinase (CPK)

Localization (recorded) of CPK associated with disorders of creatine metabolism
5) Confidence 0.73 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2570682 Disease Relevance 0.69 Pain Relevance 0.14
Primary laboratory analysis showed leukocytosis with left shift, hypercalcemia, mildly elevated liver enzymes, elevated creatinine level, and a significant increase in the levels of amylase, lipase and creatine protein kinase (CPK) (Table 1).
Localization (lipase) of CPK in liver associated with leukocytosis and hypercalcemia
6) Confidence 0.73 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2596162 Disease Relevance 0.83 Pain Relevance 0.24
Rhabdomyolysis is a clinical and biochemical syndrome occurring when skeletal muscle cells erupt and result in release of creatine phosphokinase (CPK), lactate dehydrogenase (LDH) and myoglobin into the interstitial space and plasma.
Localization (release) of CPK in skeletal muscle cells associated with disorders of creatine metabolism, syndrome and rhabdomyolysis
7) Confidence 0.66 Published 2007 Journal Hum Exp Toxicol Section Abstract Doc Link 17884958 Disease Relevance 1.13 Pain Relevance 0.04
Concentration of serum total cholesterol, transaminases and CPK
Localization (Concentration) of CPK associated with disorders of creatine metabolism and disorder of lipid metabolism
8) Confidence 0.08 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.43 Pain Relevance 0

General Comments

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