INT194468

Context Info Confidence 0.46 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.11 Pain Relevance 0.38

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara) lipid metabolic process (Ppara)

Ppara (Mus musculus)

Pain Link Frequency Relevance Heat agonist 92 97.60 Inflammation 23 85.20 Kinase C 6 59.60 cINOD 7 51.52 metalloproteinase 1 21.16 antagonist 10 5.00 Inflammatory response 6 5.00 alcohol 3 5.00 cytokine 3 5.00 aspirin 2 5.00

Disease Link Frequency Relevance Heat Carcinoma 2 99.28 Obesity 100 98.48 Cancer 57 97.76 Hyperlipidemia 13 97.52 Disorder Of Lipid Metabolism 35 96.44 Targeted Disruption 24 95.36 Stress 11 94.72 Colorectal Cancer 25 93.40 INFLAMMATION 31 85.20 Injury 3 76.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This insulin-mediated phosphorylation of PPAR?

Positive_regulation (mediated) of Phosphorylation (phosphorylation) of PPAR

1) Confidence 0.46 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.19 Pain Relevance 0.09

serine phosphorylation promotes the degradation of PPAR?

Positive_regulation (promotes) of Phosphorylation (phosphorylation) of PPAR

2) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0.05

However, overexpression of a constitutively active form of PPAR?

Positive_regulation (overexpression) of Phosphorylation (form) of PPAR

3) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.47 Pain Relevance 0.19

In addition, db/db mice expressing an activated form of PPAR?

Positive_regulation (activated) of Phosphorylation (form) of PPAR

4) Confidence 0.21 Published 2006 Journal International Journal of Medical Sciences Section Body Doc Link PMC1525216 Disease Relevance 0.45 Pain Relevance 0.05

General Comments

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