INT194495

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.85
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 57 99.98 Very High Very High Very High
Opioid 23 96.28 Very High Very High Very High
Arthritis 87 92.16 High High
cytokine 36 91.72 High High
Inflammation 37 89.92 High High
ischemia 6 88.24 High High
agonist 16 86.16 High High
Ventral tegmentum 5 85.24 High High
Nucleus accumbens 2 82.24 Quite High
chemokine 4 80.56 Quite High
Disease Link Frequency Relevance Heat
Disease 25 95.28 Very High Very High Very High
Arthritis 87 92.16 High High
Myocardial Stunning 6 91.28 High High
Experimental Arthritis 4 90.32 High High
INFLAMMATION 37 89.92 High High
Hypoxia 2 88.88 High High
Apoptosis 7 88.72 High High
Cv Unclassified Under Development 3 88.24 High High
Coronary Artery Disease 3 87.44 High High
Myocardial Infarction 1 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single injection of morphine alters striatal expression of some genes in mice, including immediate early genes as well as transcription of cytoskeleton-related genes and proteins involved in oxidative chain [18,19].
Regulation (alters) of Transcription (transcription) of immediate early associated with morphine
1) Confidence 0.26 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.05 Pain Relevance 1.19
The proto-oncogene c-fos encodes a nuclear phosphoprotein (c-Fos). c-Fos, in a complex with products of another proto-oncogene, c-jun (AP-1), regulates the expression of AP-1 binding genes at the transcriptional level [8].
Regulation (regulates) of Transcription (transcriptional) of AP-1
2) Confidence 0.25 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 1.50 Pain Relevance 0.43
ligands may be due to their ability to inhibit the activity of key transcription factors such as activator protein-1 (AP-1) and nuclear factor ?
Regulation (activity) of Transcription (transcription) of activator protein-1
3) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526548 Disease Relevance 0.65 Pain Relevance 0.49
ligands may be due to their ability to inhibit the activity of key transcription factors such as activator protein-1 (AP-1) and nuclear factor ?
Regulation (activity) of Transcription (transcription) of AP-1
4) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526548 Disease Relevance 0.65 Pain Relevance 0.49

General Comments

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