INT194691

Context Info Confidence 0.23 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.04

cytosol (MAP2K1, MAP2K3) signal transduction (MAP2K1, MAP2K3) nucleoplasm (MAP2K3) mitochondrion (MAP2K1) Golgi apparatus (MAP2K1) cytoplasm (MAP2K1)

MAP2K1 (Homo sapiens) MAP2K3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 34 87.16 Inflammation 30 10.44 rheumatoid arthritis 4 5.00 Arthritis 3 5.00 Central nervous system 1 5.00 Inflammatory response 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 31 10.44 Autoimmune Disease 14 5.00 Disease 10 5.00 Hypersensitivity 7 5.00 Stress 6 5.00 Rheumatoid Arthritis 4 5.00 Arthritis 3 5.00 Necrosis 3 5.00 Asthma 3 5.00 Sepsis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the p38 MAPK cascade, MEKK4 (an MKKK) activates MKK3, MKK4, or MKK6, which subsequently phosphorylate p38 MAPK at Thr180 and Tyr182 [21,22] (Fig. 1).

MKK Positive_regulation (activates) of MKK3

1) Confidence 0.23 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.04

General Comments

This test has worked.