INT194716

Context Info Confidence 0.04 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cytosol (VAV1, ZAP70) plasma membrane (VAV1, ZAP70) cytoplasm (ZAP70)

VAV1 (Homo sapiens) ZAP70 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 34 49.68 Inflammation 30 5.00 rheumatoid arthritis 4 5.00 Arthritis 3 5.00 Central nervous system 1 5.00 Inflammatory response 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 31 5.00 Autoimmune Disease 14 5.00 Disease 10 5.00 Hypersensitivity 7 5.00 Stress 6 5.00 Rheumatoid Arthritis 4 5.00 Arthritis 3 5.00 Necrosis 3 5.00 Asthma 3 5.00 Sepsis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CD28 co-stimulation augments the recruitment of Vav to LAT and Zap-70 and increases Zap-70 mediated Vav phosphorylation [23].

Positive_regulation (augments) of Vav Binding (recruitment) of Zap-70

1) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0

General Comments

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