INT195

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Context Info
Confidence 0.48
First Reported 1977
Last Reported 2008
Negated 0
Speculated 3
Reported most in Abstract
Documents 16
Total Number 23
Disease Relevance 15.55
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4a) extracellular region (C4a) molecular_function (C4a)
Anatomy Link Frequency
plasma 4
nerve 1
microglia 1
C4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 69 99.68 Very High Very High Very High
Inflammatory marker 5 98.44 Very High Very High Very High
Eae 2 95.40 Very High Very High Very High
ischemia 4 94.96 High High
abdominal pain 5 94.64 High High
Inflammation 3 91.28 High High
Neuropathic pain 4 91.12 High High
Peripheral nerve injury 3 90.04 High High
Spinal cord 3 88.24 High High
Pain 6 87.64 High High
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 48 99.84 Very High Very High Very High
Myocardial Infarction 32 99.84 Very High Very High Very High
Cv General 3 Under Development 69 99.68 Very High Very High Very High
Disease 408 99.44 Very High Very High Very High
Cv Unclassified Under Development 4 98.52 Very High Very High Very High
INFLAMMATION 15 98.44 Very High Very High Very High
Reperfusion Injury 4 97.28 Very High Very High Very High
Adhesions 3 95.36 Very High Very High Very High
Pressure And Volume Under Development 9 95.20 Very High Very High Very High
Neuropathic Pain 7 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At surgery, a dural-encased structure was discovered connecting the C-4 and C-5 nerve roots within the spinal canal.
Gene_expression (connecting) of C-4 in nerve
1) Confidence 0.48 Published 1994 Journal J. Neurosurg. Section Abstract Doc Link 8113869 Disease Relevance 0.17 Pain Relevance 0.28
Many of the commonly regulated transcripts are immune related and include the complement components C1q, C3, and C4, which we find are expressed only by microglia.
Gene_expression (expressed) of C4 in microglia
2) Confidence 0.32 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17687047 Disease Relevance 0.83 Pain Relevance 0.77
METHODS: The plasmatic levels of C1-INH, C3c and c4 in 30 patients affected by unstable angina, and those of 22 clinically healthy subjects (control group) were evaluated (Nefelometer Behering).
Gene_expression (levels) of c4
3) Confidence 0.30 Published 2002 Journal Minerva Cardioangiol Section Body Doc Link 12473987 Disease Relevance 0.10 Pain Relevance 0
[Evaluation of C3c, C4 and C1-esterase inhibitor (C1-INH) during unstable angina].
Gene_expression ([Evaluation) of C4 associated with angina
4) Confidence 0.30 Published 2002 Journal Minerva Cardioangiol Section Title Doc Link 12473987 Disease Relevance 0.37 Pain Relevance 0.23
The aim of this study is to investigate the plasmatic levels of some complement components (C3c, C4 and C1-INH) during unstable angina (C1-INH) and their different concentrations in relation to the different myocardial areas affected by ischemia.
Spec (investigate) Gene_expression (levels) of C4 associated with angina and ischemia
5) Confidence 0.27 Published 2002 Journal Minerva Cardioangiol Section Abstract Doc Link 12473987 Disease Relevance 0.46 Pain Relevance 0.22
RESULTS: No statistically significant differences were found in plasmatic levels of C3c, C4 and C1-INH between the group of patients and the control group.
Gene_expression (levels) of C4
6) Confidence 0.27 Published 2002 Journal Minerva Cardioangiol Section Body Doc Link 12473987 Disease Relevance 0.08 Pain Relevance 0
In those with hypocomplementemia, there were low levels of C1q, C4 and, occasionally, C3, compatible with activation of the classic complement pathway.
Gene_expression (levels) of C4
7) Confidence 0.27 Published 1977 Journal N. Engl. J. Med. Section Abstract Doc Link 17067 Disease Relevance 0.66 Pain Relevance 0.08
During a 4-yr period of treatment with danazol, the patient was virtually asymptomatic, despite levels of C4 and C1 inhibitor that remained below normal limits, and there have been no major side effects that could be attributed to treatment with androgens.
Gene_expression (levels) of C4
8) Confidence 0.21 Published 1995 Journal Am. J. Gastroenterol. Section Abstract Doc Link 7872288 Disease Relevance 0.82 Pain Relevance 0.25
Plasma C3 and C4 levels in acute myocardial infarction showed no relationship with peak CPK levels.
Gene_expression (levels) of C4 in Plasma associated with myocardial infarction
9) Confidence 0.19 Published 1999 Journal Indian Heart J Section Abstract Doc Link 10721642 Disease Relevance 0.70 Pain Relevance 0.14
Also, C3 and C4 serum levels in patients with SA and UAP (126+/-16 and 31+/-7 mg/dl) were significantly higher than those in control subjects (p<0.01, p<0.03, respectively).
Gene_expression (levels) of C4 associated with angina
10) Confidence 0.17 Published 2005 Journal APMIS Section Abstract Doc Link 15799759 Disease Relevance 1.50 Pain Relevance 0.67
Plasma C3 and C4 peak levels were significantly higher in patients with AMI (141+/-29 and 35+/-11 mg/dl) and NQMI (136+/-13 and 35+/-7 mg/dl) than in patients with SA (128+/-14 and 27+/-10 mg/dl) and the control subjects (114+/-22 and 22+/-7 mg/dl) (p<0.03).
Gene_expression (higher) of C4 in Plasma associated with angina and myocardial infarction
11) Confidence 0.14 Published 2005 Journal APMIS Section Abstract Doc Link 15799759 Disease Relevance 1.42 Pain Relevance 0.65
Although C3 and C4 were higher in ACS and SA, the systemic levels of inflammatory markers in patients with SA and UAP were lower than those found in the AMI and NQMI groups.
Gene_expression (higher) of C4 associated with acute coronary syndrome, angina, inflammatory marker and myocardial infarction
12) Confidence 0.13 Published 2005 Journal APMIS Section Abstract Doc Link 15799759 Disease Relevance 1.58 Pain Relevance 0.74
At 1-week follow-up, there were no significant differences between the plasma levels of C3 and C4 in patients with UAP (p>0.05).
Gene_expression (levels) of C4 in plasma associated with angina
13) Confidence 0.13 Published 2005 Journal APMIS Section Abstract Doc Link 15799759 Disease Relevance 1.88 Pain Relevance 0.90
However, plasma levels of C3 and C4 were significantly different between days in patients with AMI and NQMI (p<0.0001).
Gene_expression (levels) of C4 in plasma associated with myocardial infarction
14) Confidence 0.11 Published 2005 Journal APMIS Section Abstract Doc Link 15799759 Disease Relevance 1.96 Pain Relevance 0.91
Laboratory testing show low serum levels of C4 with normal levels of C3.
Gene_expression (levels) of C4
15) Confidence 0.10 Published 2006 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 16556528 Disease Relevance 0.62 Pain Relevance 0.14
ESR and levels of anti-dsDNA, C3, and C4 were determined locally at the participating centers.
Spec (determined) Gene_expression (levels) of C4
16) Confidence 0.08 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2659367 Disease Relevance 0.19 Pain Relevance 0
C3 and C4 levels
Gene_expression (levels) of C4
17) Confidence 0.08 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2659367 Disease Relevance 0.56 Pain Relevance 0
C3 and C4 levels were available for 1,463 assessments (96.9%) and 1,366 assessments (90.5%), respectively.
Gene_expression (levels) of C4
18) Confidence 0.08 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2659367 Disease Relevance 0.56 Pain Relevance 0
For C3 and C4 levels, the categories were normal, low, and very low (less than or equal to half the lower limit of normal).
Gene_expression (levels) of C4
19) Confidence 0.08 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2659367 Disease Relevance 0.16 Pain Relevance 0
The concentration of routine laboratory parameters, components of the complement system (C3, C4, C5, C1 inhibitor, total hemolytic complement, C3d, and C5a), circulating interleukins (IL-6 and IL-8) and soluble adhesion molecules (sICAM-1 and sE-selectin) were determined.
Spec (determined) Gene_expression (concentration) of C4 associated with adhesions
20) Confidence 0.07 Published 1999 Journal Pediatr Cardiol Section Abstract Doc Link 9986887 Disease Relevance 0.17 Pain Relevance 0.11

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