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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.75
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
Anatomy Link Frequency
cleavage 2
covering 1
F2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 99.52 Very High Very High Very High
Glutamate 24 91.92 High High
cva 1 91.12 High High
Inflammation 17 90.20 High High
cytokine 15 79.48 Quite High
rheumatoid arthritis 3 76.96 Quite High
Angina 1 71.08 Quite High
Inflammatory mediators 3 54.80 Quite High
antagonist 9 20.72 Low Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 25 97.96 Very High Very High Very High
Adhesions 7 97.56 Very High Very High Very High
Diabetes Mellitus 67 96.52 Very High Very High Very High
Coronary Artery Disease 36 96.04 Very High Very High Very High
Renal Disease 27 95.72 Very High Very High Very High
Cv General 3 Under Development 2 91.12 High High
INFLAMMATION 21 90.20 High High
Brain Injury 10 87.52 High High
Hypertrophy 3 84.96 Quite High
Penetrating Head Injuries 5 81.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thrombin, a serine protease generated by cleaving pro-thrombin, is an essential component of the coagulation cascade.
Protein_catabolism (cleaving) of thrombin
1) Confidence 0.26 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.85 Pain Relevance 0.12
A unique N-terminal fragment of OPN (trOPN), produced by thrombin cleavage has previously been shown to be present in plasma and milk and may have physiologically distinct roles[17]-[19].
Protein_catabolism (cleavage) of thrombin in cleavage
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0 Pain Relevance 0
However, once cleaved, (pro)thrombin was observed on fibrin fibers, covering the whole thrombus.
Protein_catabolism (cleaved) of thrombin in covering associated with thrombosis
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2861630 Disease Relevance 0.24 Pain Relevance 0
In vitro studies have reported that the N-terminal fragments of OPN generated by both thrombin cleavage and matrix metalloproteinase (MMP) cleavage induce enhanced adhesion compared with the effects of full-length OPN.
Protein_catabolism (cleavage) of thrombin in cleavage associated with metalloproteinase and adhesions
4) Confidence 0.06 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.66 Pain Relevance 0.35

General Comments

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