INT195101

Context Info Confidence 0.31 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.02 Pain Relevance 0.18

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)

Anatomy Link Frequency extracellular matrix 2 Gfap (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 23 95.40 Inflammatory mediators 3 69.08 cytokine 9 63.60 cva 1 63.36 Inflammation 6 5.00 Nerve growth factor 4 5.00 ketamine 2 5.00 Central nervous system 1 5.00 anesthesia 1 5.00 Multiple sclerosis 1 5.00

Disease Link Frequency Relevance Heat Hypertrophy 3 99.62 Penetrating Head Injuries 5 97.72 Injury 55 86.84 Brain Injury 10 70.20 INFLAMMATION 10 68.68 Cv General 3 Under Development 1 63.36 Disease 4 56.68 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 34.40 Viral Meningitis 1 34.08 Stab Wounds 15 19.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In summary, this study on the effect of a penetrating brain injury in mice lacking IL-1R1 demonstrates that IL-1R1 deletion results in: 1) attenuated hypertrophy of astrocytes; 2) delayed cellular GFAP induction; 3) diminished induction of PAR1; 4) intact induction of extracellular matrix proteins and 5) intact induction of glutamate transporters, glutamine synthetase and S-100B.

Negative_regulation (delayed) of Positive_regulation (induction) of GFAP in extracellular matrix associated with hypertrophy, glutamate and penetrating head injuries

1) Confidence 0.31 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 1.02 Pain Relevance 0.18

General Comments

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