INT195105

Context Info Confidence 0.37 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.41 Pain Relevance 0.91

signal transduction (F2r) plasma membrane (F2r) signal transducer activity (F2r)

Anatomy Link Frequency urothelial cells 2 F2r (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 74 98.52 Glutamate 23 97.60 Nerve growth factor 18 94.64 Calcitonin gene-related peptide 20 87.52 cva 1 84.40 Inflammatory response 12 82.16 agonist 16 79.24 metalloproteinase 2 77.04 neuropeptide release 2 62.24 Neuropeptide 12 60.52

Disease Link Frequency Relevance Heat INFLAMMATION 97 98.52 Hypertrophy 3 90.64 Encephalitis 1 86.96 Penetrating Head Injuries 5 86.84 Cv General 3 Under Development 1 84.40 Brain Injury 10 80.80 Injury 63 78.24 Vasculitis 1 74.44 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 55.44 Viral Meningitis 1 55.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, following acute and chronic inflammation, probably because of the shedding of urothelial cells bearing PARs, both PAR1 and PAR2 expression are reduced [24].

Negative_regulation (reduced) of Gene_expression (expression) of PAR1 in urothelial cells associated with inflammation

1) Confidence 0.37 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.51 Pain Relevance 0.28

The induced levels of the protease-activated receptor, PAR-1, were significantly attenuated in IL-1R1-null mice.

Negative_regulation (attenuated) of Gene_expression (levels) of PAR-1

2) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.91 Pain Relevance 0.17

Fig. 8 examines the effect of exposure to neurotrophic factors on expression of functional PAR1/4 receptors, measured from PKC?

Negative_regulation (receptors) of Gene_expression (expression) of PAR1

3) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.45

General Comments

This test has worked.