INT195161

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.96
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR5) plasma membrane (TLR5) intracellular (TLR5)
Anatomy Link Frequency
epithelial cells 2
lymphocyte 1
alveolar macrophages 1
TLR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 18 96.76 Very High Very High Very High
cytokine 90 92.56 High High
withdrawal 1 85.16 High High
Pain 6 58.96 Quite High
cva 1 50.80 Quite High
adenocard 3 26.80 Quite Low
chemokine 7 24.84 Low Low
Arthritis 1 9.28 Low Low
Inflammation 39 5.00 Very Low Very Low Very Low
Bile 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Agammaglobulinemia 1 97.36 Very High Very High Very High
INFLAMMATION 49 96.40 Very High Very High Very High
Obesity 229 95.24 Very High Very High Very High
Granuloma 3 93.96 High High
Cancer 5 90.00 High High
Lung Cancer 3 88.88 High High
Syndrome 22 88.80 High High
Infection 90 86.40 High High
Mycobacterial Infection 83 82.80 Quite High
Sarcoma 1 79.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The same study found that TLR3 and TLR5 were expressed exclusively on alveolar macrophages and that TLR2 and IL-4 expression were inversely correlated.
Gene_expression (expressed) of TLR5 in alveolar macrophages
1) Confidence 0.49 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.50 Pain Relevance 0.03
For example, human peripheral blood monocytes and macrophages from lung tissue or colon express TLR1, TLR2, TLR3, TLR4 and TLR5 [20], whereas gut epithelial cells express TLR3 and TLR5 only [21].
Gene_expression (express) of TLR5 in epithelial cells
2) Confidence 0.49 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.74 Pain Relevance 0.10
For example, human peripheral blood monocytes and macrophages from lung tissue or colon express TLR1, TLR2, TLR3, TLR4 and TLR5 [20], whereas gut epithelial cells express TLR3 and TLR5 only [21].
Gene_expression (express) of TLR5 in epithelial cells
3) Confidence 0.49 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.73 Pain Relevance 0.09
g/ml flagellin (target TLR5), 10 ?
Gene_expression (target) of TLR5
4) Confidence 0.44 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
We observed functional variations in her TLR 5 gene and two coagulation variations (heterozygous TF603 and PAI-1 4G-4G homozygosity) associated with thrombotic events.


Gene_expression (gene) of TLR 5
5) Confidence 0.30 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1538604 Disease Relevance 0.87 Pain Relevance 0.18
Primary human IECs constitutively express TLR3 and TLR5, but only low levels of TLR2 and TLR4.
Gene_expression (express) of TLR5
6) Confidence 0.26 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0 Pain Relevance 0.05
However, several TLRs such as TLR2, TLR4, TLR5, and TLR9 are expressed on the apical side of the IECs and important for the recognition of molecules from commensal bacteria, which is crucial to trigger innate immune responses that are required to prevent exaggerated adaptive immunity to the intestinal microbiota [61].
Gene_expression (expressed) of TLR5
7) Confidence 0.20 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.07 Pain Relevance 0.04
Genes that belong to this pathway are Toll-like receptor 5, 7, and 8 (TLR5, TLR7, TLR8), CD14 molecule (CD14), lymphocyte antigen 96 (LY96; also known as MD-2), Bruton agammaglobulinemia tyrosine kinase (BTK) [29], and myeloid differentiation primary response gene (88) (Myd88).
Gene_expression (molecule) of TLR5 in lymphocyte associated with agammaglobulinemia
8) Confidence 0.09 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2925326 Disease Relevance 1.04 Pain Relevance 0

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