INT19520

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Context Info
Confidence 0.37
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.57
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SDHB) mitochondrion (SDHB) small molecule metabolic process (SDHB)
oxidoreductase activity (SDHB)
SDHB (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 16 98.52 Very High Very High Very High
Analgesic 2 96.12 Very High Very High Very High
anticonvulsant 1 95.68 Very High Very High Very High
Bile 1 73.28 Quite High
noradrenaline 4 73.04 Quite High
Catecholamine 30 61.60 Quite High
Dopamine 3 39.12 Quite Low
Neuropeptide 2 22.56 Low Low
headache 3 9.44 Low Low
imagery 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 5 97.28 Very High Very High Very High
Disease 20 95.88 Very High Very High Very High
Necrosis 1 94.72 High High
Cancer 53 89.60 High High
Hypertension 14 87.20 High High
Hypoxia 1 87.16 High High
Pheochromocytoma 50 84.88 Quite High
Paraganglioma 48 74.64 Quite High
Neuroendocrine Cancer 1 69.56 Quite High
Chronic Subdural Hematoma 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The SEPS procedure provided a mean reduction in SDH thickness of 27.3% compared with 37.9% with bur hole (p = 0.05) when comparing the preoperative CT scan with the first postoperative CT scan.
Negative_regulation (reduction) of SDH
1) Confidence 0.37 Published 2010 Journal J. Neurosurg. Section Body Doc Link 20001585 Disease Relevance 0 Pain Relevance 0
The percentage of reduction in SDH thickness when comparing the preoperative CT scan with the most recent postoperative CT scan was 40.5% in the SEPS group and 45.4% in the bur hole group (p = 0.31).
Negative_regulation (reduction) of SDH
2) Confidence 0.37 Published 2010 Journal J. Neurosurg. Section Body Doc Link 20001585 Disease Relevance 0 Pain Relevance 0
When SDH is inhibited, the accumulation of succinate seems to inhibit the prolyl-hydroxylation of HIF and induce, as in VHL disease, an inappropriate stabilization of HIF [13].
Negative_regulation (inhibited) of SDH associated with disease
3) Confidence 0.35 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.15 Pain Relevance 0.09
These compounds were also investigated for their ability to inhibit in vitro succinate dehydrogenase (SDH).
Spec (investigated) Negative_regulation (inhibit) of SDH
4) Confidence 0.27 Published 1984 Journal Arzneimittelforschung Section Abstract Doc Link 6150719 Disease Relevance 0 Pain Relevance 0.14
PCN dramatically decreased ALT (93-97%) and SDH (63-98%) activities relative to control values from hamsters treated with AA alone, and remarkably decreased hepatic centrilobular necrosis produced by AA.
Negative_regulation (decreased) of SDH associated with necrosis and paracetamol
5) Confidence 0.05 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2068728 Disease Relevance 0.43 Pain Relevance 1.01

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