INT195266

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 8.75
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 10 12.00 Low Low
Inflammation 30 11.92 Low Low
cytokine 11 7.92 Low Low
COX-2 inhibitor 52 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
Taxol 12 5.00 Very Low Very Low Very Low
palliative 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Morphine 6 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 583 100.00 Very High Very High Very High
Obesity 230 100.00 Very High Very High Very High
Carcinoma 380 99.96 Very High Very High Very High
Heart Rate Under Development 102 97.24 Very High Very High Very High
Communicable Diseases 10 96.36 Very High Very High Very High
Myeloid Leukemia 5 95.48 Very High Very High Very High
Cholangiocarcinoma 8 93.64 High High
Congenital Anomalies 6 92.24 High High
Myocardial Infarction 33 89.44 High High
Dilated Cardiomyopathy 32 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, since p53 mutations are frequently found in HCC, Mcl-1-Bak interaction might be more stable in HCC, resulting in a stabilization of mitochondria.
Mcl-1 Binding (interaction) of associated with carcinoma
1) Confidence 0.46 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.76 Pain Relevance 0
We did not observe significant apoptosis rates in Huh7 treated with recombinant TRAIL and Mcl-1 siRNA.
Mcl-1 siRNA Binding (recombinant) of associated with apoptosis
2) Confidence 0.36 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.25 Pain Relevance 0
The importance of the Mcl-1-Bim complex for apoptotic signaling has been demonstrated previously [60].
Mcl-1-Bim Binding (complex) of associated with apoptosis
3) Confidence 0.36 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.89 Pain Relevance 0
As indicated by a significant interaction between indexed EAT and left ventricular remodelling, higher indexed EAT/LVRI-ratios in CHF patients correlated best with a reduced LV-EF.
EAT Binding (interaction) of associated with heart rate under development and obesity
4) Confidence 0.35 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.81 Pain Relevance 0
Mcl-1 is known to interact with Bak [13].
Mcl-1 Binding (interact) of
5) Confidence 0.34 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.80 Pain Relevance 0
Furthermore, as indicated by a significant interaction between indexed EAT and left ventricular remodelling, higher indexed EAT/LVRI-ratios in CHF patients correlated best with a reduced LV-EF.


EAT Binding (interaction) of associated with heart rate under development and obesity
6) Confidence 0.26 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.92 Pain Relevance 0
Bax can form also a complex with the anti-apoptotic protein Bcl-xL [53] and Mcl-1 [14].
Mcl-1 Binding (complex) of associated with apoptosis
7) Confidence 0.10 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.10 Pain Relevance 0
To all our astonishment, our group of experienced TM and TM–Sidhi practitioners was slightly better, both for the group average and for the greatest recorded sensitivity.
TM Binding (group) of
8) Confidence 0.08 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1697747 Disease Relevance 0 Pain Relevance 0
To all our astonishment, our group of experienced TM and TM–Sidhi practitioners was slightly better, both for the group average and for the greatest recorded sensitivity.
TM Binding (group) of
9) Confidence 0.08 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1697747 Disease Relevance 0 Pain Relevance 0
Moreover, there is a growing recognition that knowledge of TM is important not only because of its potential to discover new treatments, but also because of its socioeconomic, conservationist and cultural components.
TM Binding (knowledge) of
10) Confidence 0.05 Published 2007 Journal J Ethnobiol Ethnomedicine Section Body Doc Link PMC1847427 Disease Relevance 0.06 Pain Relevance 0
Given the increased use of TM, possibilities that would ensure successful integration of TM into a public health framework should be explored.
TM Binding (integration) of
11) Confidence 0.05 Published 2007 Journal J Ethnobiol Ethnomedicine Section Body Doc Link PMC1847427 Disease Relevance 0.10 Pain Relevance 0
Heptad motif in TM helix-helix interactions
TM Binding (interactions) of
12) Confidence 0.01 Published 2006 Journal BMC Struct Biol Section Body Doc Link PMC1540425 Disease Relevance 0.06 Pain Relevance 0
A significant increase in the number of structures of alpha helical membrane proteins in recent years revealed a remarkable complexity of interacting transmembrane (TM) helices.
TM Binding (interacting) of
13) Confidence 0.01 Published 2006 Journal BMC Struct Biol Section Body Doc Link PMC1540425 Disease Relevance 0 Pain Relevance 0

General Comments

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