INT195363

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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (AQR) nucleus (AQR)
Anatomy Link Frequency
neurons 4
sensory neurons 1
AQR (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 6 38.60 Quite Low
Neuropeptide 30 37.36 Quite Low
Serotonin 198 29.92 Quite Low
nociceptor 6 22.56 Low Low
Neurotransmitter 18 5.00 Very Low Very Low Very Low
interneuron 12 5.00 Very Low Very Low Very Low
TRP channel 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperoxia 666 98.48 Very High Very High Very High
Arterial-venous Cerebral Malformations 12 98.00 Very High Very High Very High
Death 6 91.28 High High
Sprains And Strains 246 89.44 High High
Hypoxia 36 79.08 Quite High
Nociception 54 24.80 Low Low
Stress 48 5.00 Very Low Very Low Very Low
Anorexia 36 5.00 Very Low Very Low Very Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Fever 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recovery of food regulation also supports the model from aggregation studies that the main site of npr-1 action is the sGC-expressing URX, AQR, and PQR neurons [18], which are not required for food regulation (Figure 4C and 4K).
Gene_expression (expressing) of AQR in neurons
1) Confidence 0.10 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.76 Pain Relevance 0
URX, AQR, PQR, SDQ, ALN, and PLN express sGCs that bind to molecular oxygen, consistent with a primary oxygen-sensing function [11].
Gene_expression (express) of AQR
2) Confidence 0.10 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.43 Pain Relevance 0
gcy-35::GFP reporter genes are expressed reliably in URX, AQR, PQR, SDQ, ALN, and BDU neurons, and variably in AVM, PLM, and PLN neurons [11,16].
Gene_expression (expressed) of AQR in neurons associated with arterial-venous cerebral malformations
3) Confidence 0.09 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.75 Pain Relevance 0
These neurons, called URX, AQR, and PQR, express five genes that encode soluble guanylate cyclase homologs (sGCs) with similarity to the NO-regulated sGCs from other animals.
Gene_expression (express) of AQR in neurons
4) Confidence 0.08 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.22 Pain Relevance 0
Four additional sGC homologs, gcy-32, gcy-34, gcy-36, and gcy-37, are coexpressed with gcy-35 and tax-4 in the URX, AQR, and PQR sensory neurons.
Gene_expression (coexpressed) of AQR in sensory neurons
5) Confidence 0.08 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.72 Pain Relevance 0
The hyperoxia avoidance defects of gcy-35 and tax-4 mutants can be rescued by transgenes expressed in the URX, AQR, and PQR neurons [11].
Gene_expression (expressed) of AQR in neurons associated with hyperoxia
6) Confidence 0.08 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.63 Pain Relevance 0

General Comments

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