INT195454

Context Info Confidence 0.45 First Reported 2006 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 7 Disease Relevance 7.65 Pain Relevance 0.85

cytosol (SAT1) small molecule metabolic process (SAT1) intracellular (SAT1) transferase activity, transferring acyl groups (SAT1) cellular nitrogen compound metabolic process (SAT1) cytoplasm (SAT1)

SAT1 (Homo sapiens)

Pain Link Frequency Relevance Heat Endocannabinoid 140 100.00 agonist 8 79.44 Cannabinoid receptor 28 79.08 Potency 4 75.08 Inflammation 23 5.00 alcohol 6 5.00 lidocaine 4 5.00 Cannabinoid 4 5.00 cINOD 3 5.00 cytokine 2 5.00

Disease Link Frequency Relevance Heat Obesity 1006 100.00 Diabetes Mellitus 140 99.18 Prostate Cancer 1 97.96 Agammaglobulinemia 2 94.64 Breast Cancer 1 94.00 Cancer 29 87.00 Colorectal Cancer 23 82.24 Carcinoma 1 79.12 Colon Cancer 3 75.20 Disorder Of Lipid Metabolism 106 74.88

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Event

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Negation

Speculation

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Disease term

On the other hand, in prostatic cancer the SSAT overexpression induces growth inhibition without determining polyamine pool depletion since SSAT activity seems to modulate ODC activity [11,34].

Spec (seems) Regulation (modulate) of SSAT associated with prostate cancer

1) Confidence 0.45 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.80 Pain Relevance 0

Possible explanations for the observed differential alterations of endocannabinoid levels in the SAT of OBT2D patients

Regulation (alterations) of SAT associated with endocannabinoid and obesity

2) Confidence 0.12 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 0.61 Pain Relevance 0.26

Possible significance of the observed alterations of the concentrations of endocannabinoids and related lipids in the SAT of OBT2D patients

Regulation (alterations) of SAT associated with endocannabinoid and obesity

3) Confidence 0.12 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.26 Pain Relevance 0.23

However, we have also found that, in the presence of T2D, obese patients do exhibit differential alterations of the SAT concentrations of the four measured lipid mediators.

Regulation (alterations) of SAT associated with diabetes mellitus and obesity

4) Confidence 0.12 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.19 Pain Relevance 0.31

As shown in Fig. 1, the SAT concentrations of AEA, OEA and PEA were significantly higher in OBT2D than in either OB or NW subjects.

Regulation (concentrations) of SAT associated with obesity

5) Confidence 0.07 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.25 Pain Relevance 0.05

Our data thus suggest that some genes in SAT 4 and SAT 8 are involved in immune-related signalling pathways such as the Toll-like receptor signalling and the Fc?

Regulation (involved) of SAT associated with obesity

6) Confidence 0.06 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2925326 Disease Relevance 1.27 Pain Relevance 0

Our data thus suggest that some genes in SAT 4 and SAT 8 are involved in immune-related signalling pathways such as the Toll-like receptor signalling and the Fc?

Regulation (involved) of SAT 8 associated with obesity

7) Confidence 0.06 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2925326 Disease Relevance 1.27 Pain Relevance 0

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