INT19549

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Context Info
Confidence 0.45
First Reported 1991
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 1.24
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
inhibitory interneurons 1
forebrain 1
dorsal horn 1
interneurons 1
hippocampus 1
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 324 100.00 Very High Very High Very High
agonist 17 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Neurotransmitter 20 99.80 Very High Very High Very High
spinal dorsal horn 3 99.18 Very High Very High Very High
Glutamate 35 99.12 Very High Very High Very High
Endogenous opioid 7 98.84 Very High Very High Very High
Pain 19 98.08 Very High Very High Very High
Hippocampus 93 95.40 Very High Very High Very High
Nucleus accumbens 8 93.00 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 45 99.12 Very High Very High Very High
Pain 28 98.08 Very High Very High Very High
Congenital Anomalies 30 80.60 Quite High
Nervous System Injury 8 69.20 Quite High
Nociception 5 62.32 Quite High
Depression 33 50.00 Quite Low
Anxiety Disorder 30 50.00 Quite Low
Repression 1 40.48 Quite Low
Pheochromocytoma 16 32.32 Quite Low
Injury 2 16.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, it has been proposed that there are potential interactions for NR2A and NR2B [27], which may also account for the variability.
NR2A Binding (interactions) of
1) Confidence 0.45 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.06 Pain Relevance 0.22
We report here that postsynaptic density-93 protein (PSD-93), a postsynaptic neuronal MAGUK, is expressed abundantly in spinal dorsal horn and forebrain, where it colocalizes and interacts with NMDAR subunits NR2A and NR2B.
NR2A Binding (interacts) of in forebrain associated with spinal dorsal horn
2) Confidence 0.41 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.46 Pain Relevance 0.50
Despite the ability of Neto1 to bind to both NR2A and NR2B subunits in vitro, the differential effect of Neto1 on NR2A- versus NR2B-containing NMDARs in vivo, might be mediated by the extracellular, membrane or cytoplasmic domains of these NR2 subunits.
NR2A Spec (might) Binding (bind) of
3) Confidence 0.27 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
Other studies indicate that the cytoplasmic domains of NR2A and NR2B preferentially associate with unique sets of proteins.
NR2A Binding (associate) of
4) Confidence 0.27 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
Despite the ability of Neto1 to bind to both NR2A and NR2B subunits in vitro, the differential effect of Neto1 on NR2A- versus NR2B-containing NMDARs in vivo, might be mediated by the extracellular, membrane or cytoplasmic domains of these NR2 subunits.
NR2A Spec (might) Binding (bind) of
5) Confidence 0.27 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
Moreover, the amount of NR2A, NR2B, and PSD-95 that co-immunoprecipitated with NR1 from crude synaptosomes was normal in Neto1-null mice, indicating that the lack of Neto1 did not alter the overall abundance of the NMDAR:PSD-95 holocomplex (Figure 6N).


NR2A Binding (amount) of
6) Confidence 0.27 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.16 Pain Relevance 0.07
In parallel experiments, we did not observe the interaction between DREAM and the NMDA receptor subunits NR1, NR2A or NR2B (Figure 6B).
NR2A Neg (not) Binding (interaction) of associated with nmda receptor
7) Confidence 0.26 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0 Pain Relevance 0.40
Although Neto1 binds to both NR2A and NR2B, the loss of Neto1 leads to a reduction in the abundance of NR2A, but not NR2B, in the PSD fraction from hippocampus and a reduction in NR2A puncta in the CA1 region.
NR2A Binding (binds) of in hippocampus associated with hippocampus
8) Confidence 0.26 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.12
Functional implications of NR2 subunits expressed on inhibitory interneurons
NR2 Binding (implications) of in inhibitory interneurons
9) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0.10 Pain Relevance 0.44
Functional implications of NR2 subunits expressed on excitatory interneurons
NR2 Binding (implications) of in interneurons
10) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.13
After blocking nonspecific protein interactions with 10% albumin in Tris-buffered saline (TBS), the nitrocellulose papers were incubated for 2 hr at room temperature with the primary antibodies: NR1 (1:1000; Pharmingen, San Diego, CA, USA), NR2A (1:1000; Zymed, San Francisco, CA, USA), NR2B (1:1000; Zymed), GluR1 (1:1500; Chemicon, Temecula, CA, USA), PSD-95 (1:2000; Affinity BioReagents, Golden, CO, USA), SAP97 (1:1000; StressGen, San Diego, CA, USA), Ca2+/calmodulin-dependent protein kinase II (?
NR2A Binding (blocking) of
11) Confidence 0.15 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0 Pain Relevance 0
We report here that postsynaptic density-93 protein (PSD-93), a postsynaptic neuronal MAGUK, is expressed abundantly in spinal dorsal horn and forebrain, where it colocalizes and interacts with NMDAR subunits NR2A and NR2B.
NR2A Binding (interacts) of in dorsal horn associated with spinal dorsal horn
12) Confidence 0.14 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.46 Pain Relevance 0.50
Electrical stimulation of the enkephalin-containing fibers in the perforant path caused the release of endogenous opioid peptides and the subsequent displacement of [3H]-[D-Ala2,N-methyl-Phe4,glyol5]enkephalin binding.
N-methyl-Phe4 Binding (binding) of associated with endogenous opioid and enkephalin
13) Confidence 0.03 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2072294 Disease Relevance 0 Pain Relevance 0.93
NR1 subunits bind the co-agonist glycine and NR2 subunits bind the neurotransmitter glutamate.
NR2 Binding (bind) of associated with glutamate, neurotransmitter and agonist
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797636 Disease Relevance 0 Pain Relevance 0.89
NR1 subunits bind the co-agonist glycine and NR2 subunits bind the neurotransmitter glutamate.
NR2 Binding (bind) of associated with glutamate, neurotransmitter and agonist
15) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797636 Disease Relevance 0 Pain Relevance 0.89

General Comments

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