INT195525

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.82
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm3) plasma membrane (Grm3) intracellular (Grm3)
signal transducer activity (Grm3)
Grm3 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 25 98.28 Very High Very High Very High
analgesia 35 95.88 Very High Very High Very High
Neuropathic pain 25 95.28 Very High Very High Very High
antagonist 5 94.20 High High
Pain 25 84.36 Quite High
Spinal cord 20 81.52 Quite High
Dorsal horn 30 80.72 Quite High
antinociception 5 68.56 Quite High
Glutamate receptor 35 66.88 Quite High
Inflammation 20 52.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 25 95.28 Very High Very High Very High
Pain 35 84.36 Quite High
INFLAMMATION 25 52.00 Quite High
Nervous System Injury 10 43.20 Quite Low
Inflammatory Pain 5 21.60 Low Low
Syndrome 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the basal expression of both mGlu2 and mGlu3 mRNA was regulated by NF-?
Regulation (regulated) of Gene_expression (expression) of mGlu3
1) Confidence 0.04 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.05 Pain Relevance 0.24
Interestingly, LAC selectively enhances the expression of mGlu2 receptors and has no effect on the expression of mGlu3 receptors [10,15], although these two receptor subtypes are highly homologous and share similar functions in the CNS [16].
Neg (no) Regulation (effect) of Gene_expression (expression) of mGlu3
2) Confidence 0.04 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.39 Pain Relevance 0.91
B regulates the constitutive expression of mGlu2 and mGlu3 in DRG cultures.
Regulation (regulates) of Gene_expression (expression) of mGlu3
3) Confidence 0.04 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0.07
This suggests that the expression of mGlu2 and mGlu3 is differentially regulated and that unraveling the nature of this difference may lead to the identification of new targets for the treatment of neuropathic pain.
Regulation (regulated) of Gene_expression (expression) of mGlu3 associated with neuropathic pain
4) Confidence 0.04 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.38 Pain Relevance 0.86
B regulates the constitutive expression of mGlu2 and mGlu3 in DRG cultures
Regulation (regulates) of Gene_expression (expression) of mGlu3
5) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0.07

General Comments

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