INT195663

Context Info Confidence 0.16 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.18 Pain Relevance 0.22

aging (IL6) protein complex assembly (APC) cytoplasm (APC) cytosol (APC) extracellular space (IL6) chromosome organization (APC)

APC (Homo sapiens) IL6 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 20 95.40 Inflammatory response 1 71.84 cytokine 1 67.48 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Sepsis 7 98.20 Apoptosis 3 96.16 INFLAMMATION 21 95.40 Pancreatitis 44 88.80 Necrosis 2 68.12 Cancer 1 67.76 Thrombosis 1 65.72 Burns 1 43.84 Injury 1 43.40 Disease 5 29.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While the underlying mechanism remains incompletely understood, recombinant APC decreased the levels of IL-6 and D-dimer and reduced mortality in severe sepsis patients [12].

APC Negative_regulation (decreased) of Gene_expression (levels) of IL-6 associated with sepsis

1) Confidence 0.16 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.18 Pain Relevance 0.22

General Comments

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