INT195672

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.76
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
plasma 2
oligodendrocytes 1
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 46 93.44 High High
Kinase C 14 83.40 Quite High
Versed 1 60.96 Quite High
anesthesia 8 57.12 Quite High
imagery 2 36.64 Quite Low
abdominal pain 1 28.12 Quite Low
antagonist 1 8.48 Low Low
corticosteroid 3 7.60 Low Low
Central nervous system 7 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 4 100.00 Very High Very High Very High
Pulmonary Edema 2 99.68 Very High Very High Very High
Pre-eclampsia 20 99.52 Very High Very High Very High
Sepsis 64 97.88 Very High Very High Very High
Hypertension 10 96.08 Very High Very High Very High
Injury 24 94.76 High High
Pathologic Constriction 63 94.12 High High
INFLAMMATION 49 93.44 High High
Habitual Abortion 1 93.08 High High
Burns 2 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that randomization of APC was not possible after publication of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study, our goal was to develop a prospective cohort of patients who survived an episode of severe sepsis and who were similar in all respects except for the receipt, or not, of APC.
Localization (randomization) of APC associated with sepsis
1) Confidence 0.74 Published 2007 Journal Crit Care Section Body Doc Link PMC2246225 Disease Relevance 0.39 Pain Relevance 0
Plasma samples supplemented with benzamidine, a reversible inhibitor of thrombin, APC, and trypsin-like proteases, were incubated in the wells for the capture of APC and PC.
Localization (capture) of APC in Plasma
2) Confidence 0.61 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.13 Pain Relevance 0
This is the rationale for the use of aPC, and not only PC, as a therapeutic agent for severe sepsis.
Localization (use) of aPC associated with sepsis
3) Confidence 0.51 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.97 Pain Relevance 0.09
Our results agree with an investigation in endotoxemic rats demonstrating an APC-induced decrease in the lung wet/dry weight ratio in parallel with reduced accumulation of leukocytes in the lungs and a fall in the plasma concentration of TNF?
Localization (decrease) of APC in plasma associated with pulmonary edema
4) Confidence 0.23 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.48 Pain Relevance 0.13
To localize stathmin to oligodendrocytes, we used a mouse monoclonal antibody against Adenomatus polyposis coli (APC), a marker for oligodendroglial cells (1:200; Calbiochem).
Localization (localize) of APC in oligodendrocytes associated with familial adenomatous polyposis
5) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.20 Pain Relevance 0
As an alternative, electrocautery or APC was used under FB in some patients.
Localization (electrocautery) of APC
6) Confidence 0.12 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2556644 Disease Relevance 0.69 Pain Relevance 0.09
The primary objective of our study was to determine the status of natural coagulation inhibitors and APC?
Spec (determine) Localization (status) of APC
7) Confidence 0.06 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999706 Disease Relevance 0.91 Pain Relevance 0

General Comments

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