INT196003

Context Info Confidence 0.30 First Reported 2006 Last Reported 2007 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 3.38 Pain Relevance 0.50

signal transduction (Cd34) extracellular region (Cd34) cell motility (Cd34) cell adhesion (Cd34) plasma membrane (Cd34) transcription factor binding (Cd34)

Cd34 (Rattus norvegicus)

Pain Link Frequency Relevance Heat fibrosis 1 99.68 dexamethasone 40 92.48 Central nervous system 4 59.16 cva 4 35.08 Pain 5 31.28 peripheral neuropathy 6 5.00 imagery 5 5.00 aspirin 3 5.00 Inflammation 1 5.00 vincristine 1 5.00

Disease Link Frequency Relevance Heat Sarcoma 11 99.78 Fibrosis 1 99.68 Hemangiopericytoma 4 97.52 Gastrointestinal Stromal Tumor 24 96.64 Cancer 65 94.56 Disease 13 92.80 Metastasis 16 87.88 Malignant Neoplastic Disease 14 84.44 Recurrence 7 72.40 Lymphangioma 1 69.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The staining for CD34 and VEGFR-3 is most intense out of these [1].

Regulation (intense) of CD34

1) Confidence 0.30 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1555613 Disease Relevance 0.89 Pain Relevance 0

Even after the detection of the mesenteric primary, the patient was initially treated as a mesenteric sarcoma as histopathology showed a sarcoma which was positive for CD34 and vimentin antigen.

Regulation (positive) of CD34 associated with sarcoma

2) Confidence 0.09 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1654154 Disease Relevance 1.52 Pain Relevance 0.11

Hemangiopericytoma is one of the lesions that bears a close resemblance with SFT of soft tissues (fascicular pattern, fibrosis, and vimentin, CD34, and bcl2 immunoreactivity).

Regulation (immunoreactivity) of CD34 associated with fibrosis and hemangiopericytoma

3) Confidence 0.05 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1913496 Disease Relevance 0.90 Pain Relevance 0.05

A retrospective study addressed specifically this issue; the total number of CD34 cells collected was not affected by previous duration or dose of thalidomide, or duration between thalidomide cessation and mobilization (Ghobrial et al 2003), while in another study the median number of CD34 was affected by the time from thalidomide discontinuation (Abdelkefi et al 2005).

Neg (not) Regulation (affected) of CD34

4) Confidence 0.05 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2374936 Disease Relevance 0.07 Pain Relevance 0.34

General Comments

This test has worked.